Evidence map›Paper›PMID 36165184›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Nexinhib20 Inhibits Neutrophil Adhesion and β

Wei Liu, Chunxia G Cronin, Ziming Cao, Chengliang Wang, Jianbin Ruan, Sunitha Pulikkot, Alexxus Hall, Hao Sun, Alex Groisman, Yunfeng Chen and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Blocking HXAmBio · 2024
    Article
  7. Article
  8. Blocking HXAbioRxiv : the preprint server for biology · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Targeting integrin pathways: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Wei LiuDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT.
Chunxia G CroninPat and Jim Calhoun Cardiology Center, School of Medicine, UConn Health, Farmington, CT.
Ziming CaoDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT.ORCID 0000-0002-7570-3400
Chengliang WangDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT.ORCID 0000-0001-5249-4856
Jianbin RuanDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT.
Sunitha PulikkotDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT.ORCID 0000-0002-4960-250X
Alexxus HallDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT.
Hao SunDepartment of Medicine, University of California San Diego, La Jolla, CA.
Alex GroismanDepartment of Physics, University of California San Diego, La Jolla, CA.
Yunfeng ChenDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX.
Anthony T VellaDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT.
Liang HuAcademy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; and.
Bruce T LiangPat and Jim Calhoun Cardiology Center, School of Medicine, UConn Health, Farmington, CT; zfan@uchc.edu bliang@uchc.edu.
Zhichao FanDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT; zfan@uchc.edu bliang@uchc.edu.ORCID 0000-0001-5385-9626
UConn Health · USUniversity of California San Diego · USLa Jolla Institute for Immunology · USShanghai University of Traditional Chinese Medicine · CNThe University of Texas Medical Branch at Galveston · US

Funding

Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammationR01HL145454 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI FAN, ZHICHAO · 2019 to 2023
$2.1M
A New Drug Therapy for Advanced Heart FailureR44HL152710 · NHLBI · CORNOVUS PHARMACEUTICALS, INC. · PI VAN ALLEN, R MARK · 2020 to 2021
$2.0M
Inhibiting biomechanical platelet aggregation to prevent arterial thrombosis without compromising hemostasisR00HL153678 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHEN, YUNFENG · 2022 to 2024
$746k
A New Anti-inflammatory Therapy for Ischemic StrokeR41HL156322 · NHLBI · CORNOVUS PHARMACEUTICALS, INC. · PI LIANG, BRUCE · 2021 to 2021
$433k
American Heart Association-American Stroke Association 18CDA34110426NHLBI NIH HHS R00 HL153678NHLBI NIH HHS R01 HL145454NHLBI NIH HHS R41 HL156322NHLBI NIH HHS R44 HL152710
6 · The paper itself

Abstract

Neutrophils are critical for mediating inflammatory responses. Inhibiting neutrophil recruitment is an attractive approach for preventing inflammatory injuries, including myocardial ischemia-reperfusion (I/R) injury, which exacerbates cardiomyocyte death after primary percutaneous coronary intervention in acute myocardial infarction. In this study, we found out that a neutrophil exocytosis inhibitor Nexinhib20 inhibits not only exocytosis but also neutrophil adhesion by limiting β

Indexed as

CD18 AntigensNeutrophilsAnimalsCalciumCell AdhesionGuanosineGuanosine TriphosphateHumansInterleukin-8MiceMice, Inbred C57BLPolyphosphatesrac1 GTP-Binding ProteinCalciumCD18 AntigensGuanosineGuanosine TriphosphateInterleukin-8Polyphosphatesrac1 GTP-Binding Proteintriphosphoric acid

Identifiers

PMID36165184
PMCPMC9529951
OpenAlexW4297252759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.