Evidence map›Paper›PMID 36165173›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Deficiency of p53 Causes the Inadequate Expression of miR-1246 in B Cells of Systemic Lupus Erythematosus.

Qing Zhang, Yu Liu, Jieyue Liao, Ruifang Wu, Yi Zhan, Peng Zhang, Shuangyan Luo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qing ZhangDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yu LiuDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jieyue LiaoDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ruifang WuDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yi ZhanDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Peng ZhangDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shuangyan LuoDepartment of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China dr.shuangyanluo@csu.edu.cn.ORCID 0000-0001-6506-2040
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Underexpression of p53 is considered the leading cause of the decreased miR-1246 expression in B cells of systemic lupus erythematosus (SLE) patients, yet the exact mechanism of action still remains unclear. To further explore the molecular mechanism of p53 upregulating miR-1246 expression, we targeted the methylation and acetylation of histone H3 in the miR-1246 promoter region of SLE B cells. We found that increased histone H3 trimethylation at Lys

Indexed as

B-LymphocytesLupus Erythematosus, SystemicMicroRNAsTumor Suppressor Protein p53CREB-Binding ProteinHistonesHumansImmunoglobulin GCREB-Binding ProteinHistonesImmunoglobulin GMicroRNAsMIRN1246 microRNA, humanTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID36165173
PMCPMC9527209
OpenAlexW4297265420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.