ArticleeLife2022
Quantitative MRI reveals differences in striatal myelin in children with DLD.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The neuroanatomy of developmental language disorder: a systematic review and meta-analysis.Nature human behaviour · 2024Pooled it
- The Neural Cost of Language Processing: Broader Network Recruitment in Adults With Developmental Language Disorder.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Subcortical correlates of developmental language disorder: more than the neostriatum.Brain communications · 2026Article
- Developmental Language Disorder as a Multidimensional Neurodevelopmental Spectrum: Implications for Diagnosis.Journal of speech, language, and hearing research : JSLHR · 2025Review
- Caudate nucleus atrophy as a neuroimaging feature of mild cognitive impairment induced by occupational aluminum exposure.Scientific reports · 2025Article
- Initial evidence of altered functional network connectivity in children with developmental language disorder.Brain and language · 2025Article
- Impact of tissue sample preparation methods on myelin-sensitive quantitative MR imaging.Magnetic resonance in medicine · 2025Article
- Brain Complexity and Parametrization of Power Spectral Density in Children with Specific Language Impairment.Entropy (Basel, Switzerland) · 2025Article
- Impact of Tissue Sample Preparation Methods on Myelin-Sensitive Quantitative MR Imaging.bioRxiv : the preprint server for biology · 2025Article
- Subcortical brain iron and its link to verbal memory in children with developmental language disorder.Brain and language · 2025Article
- Longitudinal variation in resilient psychosocial functioning is associated with ongoing cortical myelination and functional reorganization during adolescence.Nature communications · 2024Article
- Procedural auditory category learning is selectively disrupted in developmental language disorder.Psychonomic bulletin & review · 2024Article
- Differences in Cortical Surface Area in Developmental Language Disorder.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Microstructural Properties of the Cerebellar Peduncles in Children With Developmental Language Disorder.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Bridging the Divide: Brain and Behavior in Developmental Language Disorder.Brain sciences · 2023Review
- EEG Correlates of Cognitive Functions in a Child with ASD and White Matter Signal Abnormalities: A Case Report with Two-and-a-Half-Year Follow-Up.Diagnostics (Basel, Switzerland) · 2023Article
- The contribution of theta and delta to feedback processing in children with developmental language disorder.Journal of neurodevelopmental disorders · 2023Article
- What happens in the brain?eLife · 2022Article
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Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
Abstract
Developmental language disorder (DLD) is a common neurodevelopmental disorder characterised by receptive or expressive language difficulties or both. While theoretical frameworks and empirical studies support the idea that there may be neural correlates of DLD in frontostriatal loops, findings are inconsistent across studies. Here, we use a novel semiquantitative imaging protocol - multi-parameter mapping (MPM) - to investigate microstructural neural differences in children with DLD. The MPM protocol allows us to reproducibly map specific indices of tissue microstructure. In 56 typically developing children and 33 children with DLD, we derived maps of (1) longitudinal relaxation rate R1 (1/T1), (2) transverse relaxation rate R2* (1/T2*), and (3) Magnetization Transfer saturation (MTsat). R1 and MTsat predominantly index myelin, while R2* is sensitive to iron content. Children with DLD showed reductions in MTsat values in the caudate nucleus bilaterally, as well as in the left ventral sensorimotor cortex and Heschl's gyrus. They also had globally lower R1 values. No group differences were noted in R2* maps. Differences in MTsat and R1 were coincident in the caudate nucleus bilaterally. These findings support our hypothesis of corticostriatal abnormalities in DLD and indicate abnormal levels of myelin in the dorsal striatum in children with DLD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.