Evidence map›Paper›PMID 36164648›Full record

ArticleCurrent research in structural biology2022

Regulation of the interactions between human eIF5 and eIF1A by the CK2 kinase.

Nathan Gamble, Eleanor Elise Paul, Bibin Anand, Assen Marintchev

Abstract read
In one paragraph

Article in Current research in structural biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nathan GambleDepartment of Physiology & Biophysics, Boston University School of Medicine, 700 Albany St. W336, Boston, MA, 02118, USA.
Eleanor Elise PaulDepartment of Physiology & Biophysics, Boston University School of Medicine, 700 Albany St. W336, Boston, MA, 02118, USA.
Bibin AnandDepartment of Physiology & Biophysics, Boston University School of Medicine, 700 Albany St. W336, Boston, MA, 02118, USA.
Assen MarintchevDepartment of Physiology & Biophysics, Boston University School of Medicine, 700 Albany St. W336, Boston, MA, 02118, USA.

Funding

Mechanisms of action of human translation initiation factors and their regulationR01GM134113 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MARINTCHEV, ASSEN G · 2020 to 2023
$1.4M
NIGMS NIH HHS R01 GM134113
6 · The paper itself

Abstract

Translation initiation in eukaryotes relies on a complex network of interactions that are continuously reorganized throughout the process. As more information becomes available about the structure of the ribosomal preinitiation complex (PIC) at various points in translation initiation, new questions arise about which interactions occur when, their roles, and regulation. The eukaryotic translation factor (eIF) 5 is the GTPase-activating protein (GAP) for the GTPase eIF2, which brings the initiator Met-tRNA

Indexed as

Dynamic interactionseIF1AeIF5NMRProtein-protein interactionsTranslation initiation

Identifiers

PMID36164648
PMCPMC9508154

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.