ArticleAutism research : official journal of the International Society for Autism Research2022
Measures of tonic and phasic activity of the locus coeruleus-norepinephrine system in children with autism spectrum disorder: An event-related potential and pupillometry study.
Article in Autism research : official journal of the International Society for Autism Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Transdiagnostic eye-tracking biomarkers of inattention across psychiatric disorders: a systematic review.BMC psychiatry · 2025Pooled it
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Early intervention increases reactive joint attention in autistic preschoolers with arousal regulation as mediator.European child & adolescent psychiatry · 2025Trial
- Atypical Attentional Effort During Visual Search in Autistic Adults: Evidence From Task-Evoked Pupillary Responses.Autism research : official journal of the International Society for Autism Research · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Towards Mechanism-Informed Treatments for Mental Health.Journal of neurochemistry · 2026Review
- Locus-Coeruleus Norepinephrine Functioning as a Predictor of Childhood Mental Health (LOCUS-MENTAL): Protocol for a Longitudinal Study.JMIR research protocols · 2026Article
- Novel therapeutics in autism spectrum disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Research progress on the role of the locus coeruleus in cognitive function.Frontiers in human neuroscience · 2026Review
- Inverse Association of Locus Coeruleus MRI Integrity With Structural Volume and Its Impact on Individual's Inattentiveness.Human brain mapping · 2025Article
- Mapping Resting-State Brain Functional Specialization to Neurotransmitter Profiles in Autism Spectrum Disorder.CNS neuroscience & therapeutics · 2025Article
- Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study.Molecular autism · 2025Article
- Idiosyncratic pupil regulation in autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Cortical acetylcholine dynamics are predicted by cholinergic axon activity and behavior state.Cell reports · 2024Article
- Idiosyncratic pupil regulation in autistic children.bioRxiv : the preprint server for biology · 2024Article
- Interest paradigm for early identification of autism spectrum disorder: an analysis from electroencephalography combined with eye tracking.Frontiers in neuroscience · 2024Article
- Neuroplasticity of children in autism spectrum disorder.Frontiers in psychiatry · 2024Review
- Elevated and accelerated: Locus coeruleus activity and visual search abilities in autistic children.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- The Central Noradrenergic System in Neurodevelopmental Disorders: Merging Experimental and Clinical Evidence.International journal of molecular sciences · 2023Review
- Sensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case-control study.Molecular autism · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A growing body of research suggests that locus coeruleus-norepinephrine (LC-NE) system may function differently in individuals with autism spectrum disorder (ASD). Understanding the dynamics of both tonic (resting pupil diameter) and phasic (pupil dilation response [PDR] and event-related potential [ERP]) indices may provide meaningful insights about the nature of LC-NE function in ASD. Twenty-four children with ASD and 27 age- and nonverbal-IQ matched typically developing (TD) children completed two experiments: (1) a resting eye-tracking task to measure tonic pupil diameter, and (2) a three-stimulus oddball paradigm to measure phasic responsivity using PDR and ERP. Consistent with prior reports, our results indicate that children with ASD exhibit increased tonic (resting pupil diameter) and reduced phasic (PDR and ERP) activity of the LC-NE system compared to their TD peers. For both groups, decreased phasic responsivity was associated with increased resting pupil diameter. Lastly, tonic and phasic LC-NE indices were primarily related to measures of attention-deficit/hyperactivity disorder (ADHD), and not ASD, symptomatology. These findings expand our understanding of neurophysiological differences present in ASD and demonstrate that aberrant LC-NE activation may be associated with atypical arousal and decreased responsivity to behaviorally-relevant information in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.