Evidence map›Paper›PMID 36163560›Full record

ArticleJournal of cancer research and clinical oncology2023

Case report: identification of EGFR R776H and FANCE R381H germline mutations in a patient with multiple pulmonary nodules.

Zhenzhen Wu, Yanli Wang, Linling Jin, Juan Wei, Li Han, Junyan Su, Shuliang Cao, Siyao Liu, Xiaohong Duan, Xin Zhao

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Identification ofRespiratory medicine case reports · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhenzhen Wu *Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yanli Wang *Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Linling JinDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Juan WeiDepartment of Respiratory Medicine, Jiangsu Suining People's Hospital, Xuzhou, China.
Li HanChosenMed Technology (Beijing) Co., Ltd., Beijing, China.
Junyan SuChosenMed Technology (Beijing) Co., Ltd., Beijing, China.
Shuliang CaoChosenMed Technology (Beijing) Co., Ltd., Beijing, China.
Siyao LiuChosenMed Technology (Beijing) Co., Ltd., Beijing, China.
Xiaohong DuanChosenMed Technology (Beijing) Co., Ltd., Beijing, China. xiaohongduan@chosenmedtech.com.ORCID http://orcid.org/0000-0002-5805-6168
Xin ZhaoDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. xinzhao1104@163.com.ORCID http://orcid.org/0000-0003-2860-5899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary nodules evaluation is clinically crucial because they may be the early predictors of lung cancer. Except for CT screening and serum tumor biomarkers testing, genetic alteration analysis by next-generation sequencing (NGS) technology can also help to find cancer earlier. In this study, we report a case of multiple pulmonary nodules patient with EGFR R776H and FANCE R381H germline mutations. Her father, paternal aunt, and elder uncle harbored either one or both two mutations and were found with multiple pulmonary ground-glass or sub-solid nodules. Her 7-year-old daughter also inherited the same two mutations.

Indexed as

ErbB ReceptorsFanconi Anemia Complementation Group E ProteinLung NeoplasmsMultiple Pulmonary NodulesAgedChildFemaleGerm-Line MutationHumansLungEGFR protein, humanErbB ReceptorsFANCE protein, humanFanconi Anemia Complementation Group E ProteinEGFR R776HFANCE R381HGermline mutationsMultiple pulmonary nodules

Identifiers

PMID36163560
PMCPMC11796886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.