ArticleNature biomedical engineering2022
A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis.
Article in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Clinical translation and engineering challenges of soft robotic cardiac sleeves for heart failure.Nature communications · 2026Review
- Soft robotic devices for cardiovascular medicine.Nature reviews. Cardiology · 2026Review
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Comparison between SBMA and MPC coatings on PEEK surface: stability over time and anti-inflammatory effects in vitro.Scientific reports · 2025Article
- Pre-Clinical Models of Heart Failure with Preserved Ejection Fraction: Advancing Knowledge for Device Based Therapies.Annals of biomedical engineering · 2025Review
- Real-time in vivo imaging of rodent brain response to hypoperfusion enabled by remotely controlled elastomeric micro-balloons.bioRxiv : the preprint server for biology · 2025Article
- Development of a Self-Deploying Extra-Aortic Compression Device for Medium-Term Hemodynamic Stabilization: A Feasibility Study.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- AI-Powered Multimodal Modeling of Personalized Hemodynamics in Aortic Stenosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Development of a standardized ovine aortic stenosis model: a pathomimetic platform for TAVI evaluation and durability testing.Frontiers in cardiovascular medicine · 2025Article
- Wearable and Implantable Soft Robots.Chemical reviews · 2024Review
- A water strider-inspired intestinal stent actuator for controllable adhesion and unidirectional biofluid picking.Materials today. Bio · 2024Article
- Next-Generation Cardiac Magnetic Resonance Imaging Techniques for Characterization of Myocardial Disease.Current treatment options in cardiovascular medicine · 2024Article
- Applications of 3D Printing Technology in Diagnosis and Management of Heart Failure.Current treatment options in cardiovascular medicine · 2024Article
- Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography.Nature communications · 2024Article
- Skin-inspired, sensory robots for electronic implants.Nature communications · 2024Article
- Acausal Modelling of Advanced-Stage Heart Failure and the Istanbul Heart Ventricular Assist Device Support with Patient Data.Cardiovascular engineering and technology · 2023Article
- Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling.Science robotics · 2023Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
Preclinical models of aortic stenosis can induce left ventricular pressure overload and coarsely control the severity of aortic constriction. However, they do not recapitulate the haemodynamics and flow patterns associated with the disease. Here we report the development of a customizable soft robotic aortic sleeve that can mimic the haemodynamics and biomechanics of aortic stenosis. By allowing for the adjustment of actuation patterns and blood-flow dynamics, the robotic sleeve recapitulates clinically relevant haemodynamics in a porcine model of aortic stenosis, as we show via in vivo echocardiography and catheterization studies, and a combination of in vitro and computational analyses. Using in vivo and in vitro magnetic resonance imaging, we also quantified the four-dimensional blood-flow velocity profiles associated with the disease and with bicommissural and unicommissural defects re-created by the robotic sleeve. The design of the sleeve, which can be adjusted on the basis of computed tomography data, allows for the design of patient-specific devices that may guide clinical decisions and improve the management and treatment of patients with aortic stenosis.
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Registered trials
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