ArticleNature communications2022
Genetic analysis of seed traits in Sorghum bicolor that affect the human gut microbiome.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Genomic co-localization of variation affecting agronomic and human gut microbiome traits in a meta-analysis of diverse sorghum.G3 (Bethesda, Md.) · 2024Pooled it
- Sorghum Starch and Protein Digestibility: Mechanisms, Modifications, and Health Implications.Foods (Basel, Switzerland) · 2026Review
- Genetic dissection of sorghum [Frontiers in plant science · 2026Article
- Genetic variation and historical breeding patterns in common bean (Phaseolus vulgaris L.) affect fermentation patterns by the human gut microbiome.Communications biology · 2025Article
- Temporal changes in fecal swine microbiome primarily reflectFrontiers in veterinary science · 2025Article
- Sorghum and Sorghum-Based Products: Nutritional Composition, Prebiotic Potential and Health Benefits in Gut Microbiota Interactions.International journal of food science · 2025Review
- Fecal microbiome of pigs fed diets differing in protein and amino acid content raised in thermoneutral or cyclical heat stress conditions.Frontiers in microbiology · 2025Article
- Biologically meaningful genome interpretation models to address data underdetermination for the leaf and seed ionome prediction in Arabidopsis thaliana.Scientific reports · 2024Article
- Increased Dietary Trp, Thr, and Met Supplementation Improves Performance, Health, and Protein Metabolism of Weaned Piglets under Mixed Management and Poor Housing Conditions.Animals : an open access journal from MDPI · 2024Article
- Genome to gut: crop engineering for human microbiomes.Nature reviews. Microbiology · 2023Article
- Functional genomic effects of indels using Bayesian genome-phenome wide association studies in sorghum.Frontiers in genetics · 2023Article
- Towards gut-friendly grains.Nature reviews. Genetics · 2022Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prebiotic fibers, polyphenols and other molecular components of food crops significantly affect the composition and function of the human gut microbiome and human health. The abundance of these, frequently uncharacterized, microbiome-active components vary within individual crop species. Here, we employ high throughput in vitro fermentations of pre-digested grain using a human microbiome to identify segregating genetic loci in a food crop, sorghum, that alter the composition and function of human gut microbes. Evaluating grain produced by 294 sorghum recombinant inbreds identifies 10 loci in the sorghum genome associated with variation in the abundance of microbial taxa and/or microbial metabolites. Two loci co-localize with sorghum genes regulating the biosynthesis of condensed tannins. We validate that condensed tannins stimulate the growth of microbes associated with these two loci. Our work illustrates the potential for genetic analysis to systematically discover and characterize molecular components of food crops that influence the human gut microbiome.
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