ArticleNature communications2022
Palladium-catalyzed asymmetric allylic 4-pyridinylation via electroreductive substitution reaction.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Enantioselective Pd-Catalyzed Electrochemical Dearomative Allylation of Tropones: Construction of All-C Quaternary Stereocenters.Organic letters · 2026Article
- Tunable enantioselective electrocatalytic functionalization of unactivated alkenes.Nature communications · 2026Article
- Screening and dissecting electroorganic synthesis by mass spectrometry decoupling of electrode and homogeneous processes.Nature communications · 2025Article
- Enantioselective electrochemical nickel-catalyzed vinylogous radical reactions.Science advances · 2025Article
- Electrochemically Driven Nickel-Catalyzed Enantioselective Hydro-Arylation/Alkenylation of Enones.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Electroreductively Induced Radicals for Organic Synthesis.Molecules (Basel, Switzerland) · 2023Review
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4 authors.
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Abstract
The enantioselective pyridinylation is important for providing chiral compounds bearing heterocycles of pharmaceutical interests. 4-CN-pyrinde is extensively applied in the radical pyridinylation reaction, however, its' enantioselective application is highly challenging. To achieve this goal, we propose an electrochemical catalytic activation of 4-CN-pyridine with a chiral transition metal complex instead of direct cathodic reduction. The chiral catalyst acts as the electron mediator and the transition metal catalysis in turn. The radical species from 4-CN-pyridine is captured via radical rebound by chiral catalyst, and undergoes enantioselective pyridinylation reaction. Here, we show the first method for catalytic asymmetric allylic 4-pyridinylation reactions using 4-CN-pyridine under electrochemical conditions.
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