ArticleMicrobiome2022
Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system.
Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Symbiotic Bacterial Diversity, Functional Profiling and Antibiotic Susceptibility of the Red Imported Fire Ant.Microorganisms · 2026Article
- Defensive symbionts of the European beewolf face competition from brood cell microbiota during vertical transmission.FEMS microbiology ecology · 2026Article
- Analysis of the Bacterial Community and Fatty Acid Composition in the Bacteriome of the Lac InsectMicroorganisms · 2025Article
- The microbiome of the sucking louse Linognathus stenopsis (Phthiraptera, Anoplura, Linognathiidae).Journal of medical entomology · 2025Article
- Review
- How do host age and nutrition affect density regulation of obligate versus facultative bacterial symbionts? Insights from the tsetse fly.ISME communications · 2025Article
- microRNA maintains nutrient homeostasis in the symbiont-host interaction.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cereal weevils' antimicrobial peptides: at the crosstalk between development, endosymbiosis and immune response.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- When the microbiome shapes the host: immune evolution implications for infectious disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- The role of insect gut microbiota in host fitness, detoxification and nutrient supplementation.Antonie van Leeuwenhoek · 2024Review
- The nutritional dimension of facultative bacterial symbiosis in aphids: Current status and methodological considerations for future research.Current research in insect science · 2024Review
- Coordination of host and endosymbiont gene expression governs endosymbiont growth and elimination in the cereal weevil Sitophilus spp.Microbiome · 2023Article
- Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Endosymbiont-containing germarium transcriptional survey in a cereal weevil depicts downregulation of immune effectors at the onset of sexual maturity.Frontiers in physiology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany insects house symbiotic intracellular bacteria (endosymbionts) that provide them with essential nutrients, thus promoting the usage of nutrient-poor habitats. Endosymbiont seclusion within host specialized cells, called bacteriocytes, often organized in a dedicated organ, the bacteriome, is crucial in protecting them from host immune defenses while avoiding chronic host immune activation. Previous evidence obtained in the cereal weevil Sitophilus oryzae has shown that bacteriome immunity is activated against invading pathogens, suggesting endosymbionts might be targeted and impacted by immune effectors during an immune challenge. To pinpoint any molecular determinants associated with such challenges, we conducted a dual transcriptomic analysis of S. oryzae's bacteriome subjected to immunogenic peptidoglycan fragments.
resultsWe show that upon immune challenge, the bacteriome actively participates in the innate immune response via induction of antimicrobial peptides (AMPs). Surprisingly, endosymbionts do not undergo any transcriptomic changes, indicating that this potential threat goes unnoticed. Immunohistochemistry showed that TCT-induced AMPs are located outside the bacteriome, excluding direct contact with the endosymbionts.
conclusionsThis work demonstrates that endosymbiont protection during an immune challenge is mainly achieved by efficient confinement within bacteriomes, which provides physical separation between host systemic response and endosymbionts. Video Abstract.
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