ArticleCommunications biology2022
Hippocampal cells segregate positive and negative engrams.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Article
- Restoring access to long-term social recognition memories disrupted by sleep deprivation.Science advances · 2026Article
- CA1 Engram Cell Dynamics Before and After Learning.bioRxiv : the preprint server for biology · 2026Article
- Simultaneous brain-wide single-cell recording resolves spatiotemporal memory architecture.bioRxiv : the preprint server for biology · 2026Article
- GRASPing experience-dependent protein expression signatures enriched for hippocampal engram cell synapses.Science advances · 2026Article
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Review
- Emotional shaping of spatial encoding along the dorsal ventral axis of the hippocampus.Frontiers in systems neuroscience · 2026Review
- Transcriptomic signatures of hippocampal active place avoidance memory maintenance.Frontiers in cellular neuroscience · 2026Article
- Drug-Related Engrams and Their Role in the Persistence and Recurrence of Drug-Related Behaviors.Hippocampus · 2025Review
- Article
- Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural Networks.Hippocampus · 2025Article
- Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms.PLoS biology · 2025Article
- DNA Methylation in Long-Term Memory.Physiology (Bethesda, Md.) · 2025Review
- Ventral hippocampus neurons encode meal-related memory.Nature communications · 2025Article
- Stress induces distinct social behavior states encoded by the ventral hippocampus.bioRxiv : the preprint server for biology · 2025Article
- Article
- Brain-wide immunolabeling and tissue clearing applications for engram research.Neurobiology of learning and memory · 2025Review
- Behavioral Animal Models and Neural-Circuit Framework of Depressive Disorder.Neuroscience bulletin · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The hippocampus is involved in processing a variety of mnemonic computations specifically the spatiotemporal components and emotional dimensions of contextual memory. Recent studies have demonstrated cellular heterogeneity along the hippocampal axis. The ventral hippocampus has been shown to be important in the processing of emotion and valence. Here, we combine transgenic and all-virus based activity-dependent tagging strategies to visualize multiple valence-specific engrams in the vHPC and demonstrate two partially segregated cell populations and projections that respond to appetitive and aversive experiences. Next, using RNA sequencing and DNA methylation sequencing approaches, we find that vHPC appetitive and aversive engram cells display different transcriptional programs and DNA methylation landscapes compared to a neutral engram population. Additionally, optogenetic manipulation of tagged cell bodies in vHPC is not sufficient to drive appetitive or aversive behavior in real-time place preference, stimulation of tagged vHPC terminals projecting to the amygdala and nucleus accumbens (NAc), but not the prefrontal cortex (PFC), showed the capacity drive preference and avoidance. These terminals also were able to change their capacity to drive behavior. We conclude that the vHPC contains genetically, cellularly, and behaviorally segregated populations of cells processing appetitive and aversive memory engrams.
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