Evidence map›Paper›PMID 36163254›Full record

ArticleCommunications biology2022

Striatal D1 and D2 receptor availability are selectively associated with eye-blink rates after methylphenidate treatment.

Şükrü B Demiral, Peter Manza, Erin Biesecker, Corinde Wiers, Ehsan Shokri-Kojori, Katherine McPherson, Evan Dennis, Allison Johnson, Dardo Tomasi, Gene-Jack Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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  8. Distinct Situational Cue Processing in Individuals with Kleptomania: A Preliminary Study.The international journal of neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Şükrü B DemiralNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. demiralsb@nih.gov.ORCID 0000-0002-5288-603X
Peter ManzaNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.ORCID 0000-0002-0791-357X
Erin BieseckerNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Corinde WiersDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Ehsan Shokri-KojoriNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.ORCID 0000-0001-6846-3173
Katherine McPhersonNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Evan DennisNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Allison JohnsonNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Dardo TomasiNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.ORCID 0000-0003-0183-5678
Gene-Jack WangNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.ORCID 0000-0002-5017-9905
Nora D VolkowNational Institute on Drug Abuse, Bethesda, MD, USA. nora.volkow@nih.gov.ORCID 0000-0001-6668-0908
National Institute on Alcohol Abuse and Alcoholism · USNational Institute on Drug Abuse · USUniversity of Pennsylvania · US

Funding

Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1M
Intramural NIH HHS ZIA AA000550
6 · The paper itself

Abstract

Eye-blink rate has been proposed as a biomarker of the brain dopamine system, however, findings have not been consistent. This study assessed the relationship between blink rates, measured after oral placebo) (PL) and after a challenge with oral methylphenidate (MP; 60 mg) and striatal D1 receptor (D1R) (measured at baseline) and D2 receptor (D2R) availability (measured after PL and after MP) in healthy participants. PET measures of baseline D1R ([

Indexed as

MethylphenidateCorpus StriatumDopamineHumansRacloprideReceptors, Dopamine D1Receptors, Dopamine D2DopamineMethylphenidateRacloprideReceptors, Dopamine D1Receptors, Dopamine D2

Identifiers

PMID36163254
PMCPMC9513088
OpenAlexW4297238918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.