Evidence map›Paper›PMID 36163215›Full record

ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2022

Differential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4.

Simone Bini, Laura D'Erasmo, Brenno Astiarraga, Ilenia Minicocci, Maria Palumbo, Valeria Pecce, Luca Polito, Alessia Di Costanzo, Rebecca A Haeusler, Marcello Arca and 2 more

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In one paragraph

Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Simone BiniDepartment of Translational and Precision Medicine, Sapienza University of Rome, Italy. Electronic address: simone.bini@uniroma1.it.
Laura D'ErasmoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Italy.
Brenno AstiarragaDepartment of Clinical and Experimental Medicine, University of Pisa, Italy; Pere Virgili Institute for Health Research (IISPV), Terragona, Spain.
Ilenia MinicocciDepartment of Translational and Precision Medicine, Sapienza University of Rome, Italy.
Maria PalumboDepartment of Clinical and Experimental Medicine, University of Pisa, Italy.
Valeria PecceDepartment of Translational and Precision Medicine, Sapienza University of Rome, Italy.
Luca PolitoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Italy.
Alessia Di CostanzoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Italy.
Rebecca A HaeuslerNaomi Berrie Diabetes Center and Department of Pathology and Cell Biology, Columbia University, New York, USA.
Marcello ArcaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Italy.
Ele FerranniniCNR Institute of Clinical Physiology, Pisa, Italy.
Stefania CamastraDepartment of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: stefania.camastra@unipi.it.
Sapienza University of Rome · ITUniversity of Pisa · ITColumbia University · USInstitut de Recerca Biomèdica Catalunya Sud · ESIstituto di Fisiologia Clinica · IT

Funding

Mechanisms linking insulin action with lipoprotein metabolismR01HL125649 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAEUSLER, REBECCA ANNE · 2015 to 2023
$4.2M
NHLBI NIH HHS R01 HL125649
6 · The paper itself

Abstract

BACKGROUND AND

aimAngiopoietin-like 3 (ANGPTL3) and 4 (ANGPTL4) are regulators of triglyceride storage and utilization. Bariatric surgery (BS) leads to profound changes in adipose tissue composition and energy metabolism. We evaluated the impact of BS on plasma levels of ANGPTL3 and ANGPTL4. METHODS AND

resultsTwenty-seven subjects affected by morbid obesity with or without type 2 diabetes (T2D) underwent Roux-en-Y gastric bypass (RYGB) and 18 patients with advanced T2D received Biliopancreatic Diversion (BPD). Fasting ANGPTL proteins levels, insulin sensitivity (evaluated by euglycemic hyperinsulinemic clamp), total bile acids (TBA) and free fatty acids (FFA) were measured at baseline and 1 year after surgery. Both surgical procedures resulted in the loss of fat mass, improved glucose control, and a ∼2-fold increase of insulin sensitivity. ANGPTL4 levels decreased significantly with both RYGB (26.6 ± 0.6 to 24.4 ± 0.3 ng/mL, p = 0.001) and BPD (27.9 ± 1.5 to 24.0 ± 0.5 ng/mL, p = 0.003). In contrast, ANGPTL3 concentrations did not change after RYGB but rose following BPD (225 ± 20 to 300 ± 15 ng/mL, p = 0.003). By multiple regression analysis, changes after BS in ANGPTL4 were independently associated with changes in blood glucose, (p = 0.0169) whereas changes in ANGPTL3 were associated with variations in FFA (p = 0.008) and insulin sensitivity (p = 0.043).

conclusionCirculating ANGPTL4 is reduced by BS, probably due to the loss of fat mass and improved insulin sensitivity. Conversely, ANGPTL3 levels increased after BPD, but not after RYGB, presumably because of the metabolic changes induced by the malabsorptive effect of BPD.

Indexed as

Bariatric SurgeryDiabetes Mellitus, Type 2Gastric BypassInsulin ResistanceObesity, MorbidAngiopoietin-Like Protein 3Angiopoietin-Like Protein 4Angiopoietin-like ProteinsAngiopoietinsBile Acids and SaltsBlood GlucoseFatty Acids, NonesterifiedHumansTriglyceridesAngiopoietin-Like Protein 3Angiopoietin-Like Protein 4Angiopoietin-like ProteinsAngiopoietinsANGPTL3 protein, humanANGPTL4 protein, humanBile Acids and SaltsBlood GlucoseFatty Acids, NonesterifiedTriglyceridesANGPTL3ANGPTL4Bariatric surgeryInsulin sensitivityLipid metabolismType 2 diabetes mellitus

Identifiers

PMID36163215
PMCPMC10018753
OpenAlexW4294000963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.