Evidence map›Paper›PMID 36163190›Full record

ArticleNature communications2022

Airway basal cells show a dedifferentiated KRT17

Benedikt Jaeger, Jonas Christian Schupp, Linda Plappert, Oliver Terwolbeck, Nataliia Artysh, Gian Kayser, Peggy Engelhard, Taylor Sterling Adams, Robert Zweigerdt, Henning Kempf and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 1 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Autologous transplantation of P63Cell reports. Medicine · 2024
    Trial
  4. Targeting the CD4Molecular biomedicine · 2026
    Article
  5. Review
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  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Unique nasal cell states induced by common pediatric respiratory viruses.bioRxiv : the preprint server for biology · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Benedikt Jaeger *Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.
Jonas Christian Schupp *German Center for Lung Research, BREATH, Hannover, Germany.ORCID 0000-0002-7714-8076
Linda PlappertFraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.ORCID 0000-0002-4642-383X
Oliver TerwolbeckFraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.ORCID 0000-0003-4312-0005
Nataliia ArtyshFraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.ORCID 0000-0002-9807-1506
Gian KayserInstitute of Surgical Pathology, University Medical Center, Freiburg, Germany.ORCID 0000-0002-0587-9742
Peggy EngelhardDepartment of Pneumology, University Medical Center, Freiburg, Germany.
Taylor Sterling AdamsSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4280-9070
Robert ZweigerdtLeibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-4656-0770
Henning KempfLeibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-2790-9137
Stefan LienenklausInstitute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-4790-3445
Wiebke GarrelsInstitute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-0737-1245
Irina NazarenkoInstitute for Infection Prevention and Hospital Epidemiology, Medical Center - University of Freiburg, Freiburg, Germany.
Danny JonigkGerman Center for Lung Research, BREATH, Hannover, Germany.ORCID 0000-0002-5251-2281
Malgorzata WygreckaDepartment of Biochemistry, Faculty of Medicine, Justus Liebig University, Gießen, Germany.ORCID 0000-0002-3656-2932
Denise KlattInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-0301-6206
Axel SchambachInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-2743-0070
Naftali KaminskiSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5917-4601
Antje PrasseFraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany. prasse.antje@mh-hannover.de.ORCID 0000-0002-7336-7458
Medizinische Hochschule Hannover · DEFraunhofer Institute for Toxicology and Experimental Medicine · DEYale University · USUniversity Medical Center Freiburg · DEBoston Children's Hospital · USJustus-Liebig-Universität Gießen · DEUniversity of Freiburg · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Genomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9M
Alveolar DevMAPU01HL122626 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM, HAGOOD, JAMES S. · 2014 to 2018
$3.7M
Epithelial Protective Effects of Thyroid Hormone Signaling in FibrosisR01HL141852 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$3.4M
Normal Aging Lung Cell Atlas (NALCA)U01HL145567 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$2.8M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL127349NHLBI NIH HHS R01 HL141852NHLBI NIH HHS U01 HL122626NHLBI NIH HHS U01 HL145567
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF (IPF-ABC). Single cell RNA sequencing (scRNAseq) of bronchial brushes revealed extensive reprogramming of IPF-ABC towards a KRT17

Indexed as

Idiopathic Pulmonary FibrosisAnimalsDisease Models, AnimalFibroblastsFibrosisHumansLungMicePhenotype

Identifiers

PMID36163190
PMCPMC9513076
OpenAlexW4297221499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.