Evidence map›Paper›PMID 36163187›Full record

ArticleBMC pharmacology & toxicology2022

Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats.

Heba M Fahmy, Mostafa M Ahmed, Ayman S Mohamed, Engy Shams-Eldin, Taiseer M Abd El-Daim, Amena S El-Feky, Amira B Mustafa, Mai W Abd Alrahman, Faten F Mohammed, Mohamed M Fathy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pharmacology & toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Heba M FahmyBiophysics Department, Faculty of Science, Cairo University, Giza, Egypt. hfahmy@sci.cu.edu.eg.
Mostafa M AhmedMicrobiology Department, Faculty of Science, Cairo University, Giza, Egypt.
Ayman S MohamedZoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Engy Shams-EldinSpecial Food and Nutrition Department, Food Technology Research Institute, Agriculture Research Center, 9 Gamma Street, Giza, Cairo, Egypt.
Taiseer M Abd El-DaimBiophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Amena S El-FekyBiophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Amira B MustafaBiophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Mai W Abd AlrahmanMicrobiology Department, Faculty of Science, Cairo University, Giza, Egypt.
Faten F MohammedPathology Department, Faculty of Veterinary, Cairo University, Giza, Egypt.
Mohamed M FathyBiophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Cairo University · EGAgricultural Research Center · EGBadr University in Cairo · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe Blood-Brain Barrier (BBB) is a filter for most medications and blocks their passage into the brain. More effective drug delivery strategies are urgently needed to transport medications into the brain. This study investigated the biodistribution of thymoquinone (TQ) and the effect on enzymatic and non-enzymatic oxidative stress indicators in different brain regions, either in free form or incorporated into nanocarriers as mesoporous silica nanoparticles (MSNs). Lipid bilayer-coated MSNs. MATERIALS AND

methodsMSNs and LB-MSNs were synthesized and characterized using a transmission electron microscope and dynamic light scattering to determine the particle size and zeta potential. TQ encapsulation efficiency and TQ's release profile from LB-MSNs were also examined. The impact of loading LB-MSNs with TQ-on-TQ delivery to different brain areas was examined using chromatographic measurement. Furthermore, nitric oxide, malondialdehyde (MDA), reduced glutathione, and catalase were evaluated as oxidant and antioxidant stress biomarkers. KEY

findingsThe LB-MSNs formulation successfully transported TQ to several areas of the brain, liver, and kidney, revealing a considerable increase in TQ delivery in the thalamus (81.74%) compared with that in the free TQ group and a considerable reduction in the cortex (-44%). The LB-MSNs formulation had no significant effect on TQ delivery in the cerebellum, striatum, liver, and kidney. SIGNIFICANCE: TQ was redistributed in different brain areas after being encapsulated in LB-MSNs, indicating that LB-MSNs have the potential to be developed as a drug delivery system for selective clinical application of specific brain regions.

conclusionsLB-MSNs are capable nanoplatforms that can be used to target medications precisely to specific brain regions.

Indexed as

NanoparticlesSilicon DioxideAnimalsAntioxidantsBenzoquinonesBiological AvailabilityBrainCatalaseDrug Delivery SystemsDrug LiberationGlutathioneLipid BilayersMalondialdehydeNitric OxideOxidantsPorosityAntioxidantsBenzoquinonesCatalaseGlutathioneLipid BilayersMalondialdehydeNitric OxideOxidantsSilicon DioxidethymoquinoneBiodistributionBrain areasLipid bilayerMesoporous silica nanocarriersOxidative stressThymoquinone

Identifiers

PMID36163187
PMCPMC9511777
OpenAlexW4297238087

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.