Evidence map›Paper›PMID 36163176›Full record

ReviewNeurology(R) neuroimmunology & neuroinflammation2022

Area Postrema Syndrome in Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Case Series and Literature Review.

Bo Deng, Jingguo Wang, Hai Yu, Lei Jin, Yue Qiu, Xiaoni Liu, Pengyu Wang, Xiang Zhang, Xiangjun Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bo DengFrom the Department of Neurology (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.), Huashan Hospital and Insitute of Neurology, Fudan University; National Center for Neurological Disorders (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.); and Human Phenome Institute (X.C.), Fudan University, Shanghai, China.
Jingguo WangFrom the Department of Neurology (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.), Huashan Hospital and Insitute of Neurology, Fudan University; National Center for Neurological Disorders (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.); and Human Phenome Institute (X.C.), Fudan University, Shanghai, China.
Hai YuFrom the Department of Neurology (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.), Huashan Hospital and Insitute of Neurology, Fudan University; National Center for Neurological Disorders (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.); and Human Phenome Institute (X.C.), Fudan University, Shanghai, China.
Lei JinFrom the Department of Neurology (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.), Huashan Hospital and Insitute of Neurology, Fudan University; National Center for Neurological Disorders (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.); and Human Phenome Institute (X.C.), Fudan University, Shanghai, China.
Yue QiuFrom the Department of Neurology (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.), Huashan Hospital and Insitute of Neurology, Fudan University; National Center for Neurological Disorders (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.); and Human Phenome Institute (X.C.), Fudan University, Shanghai, China.
Xiaoni LiuFrom the Department of Neurology (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.), Huashan Hospital and Insitute of Neurology, Fudan University; National Center for Neurological Disorders (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.); and Human Phenome Institute (X.C.), Fudan University, Shanghai, China.
Pengyu WangFrom the Department of Neurology (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.), Huashan Hospital and Insitute of Neurology, Fudan University; National Center for Neurological Disorders (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.); and Human Phenome Institute (X.C.), Fudan University, Shanghai, China.
Xiang ZhangFrom the Department of Neurology (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.), Huashan Hospital and Insitute of Neurology, Fudan University; National Center for Neurological Disorders (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.); and Human Phenome Institute (X.C.), Fudan University, Shanghai, China.
Xiangjun ChenFrom the Department of Neurology (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.), Huashan Hospital and Insitute of Neurology, Fudan University; National Center for Neurological Disorders (B.D., J.W., H.Y., L.J., Y.Q., X.L., P.W., X.Z., X.C.); and Human Phenome Institute (X.C.), Fudan University, Shanghai, China. xiangjchen@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTo report the frequency of area postrema syndrome (APS) in glial fibrillary acidic protein-immunoglobulin G (GFAP-IgG)-positive patients and emphasize the importance of APS among the phenotypes in autoimmune GFAP astrocytopathy.

methodsEight GFAP-IgG-positive cases with APS were retrospectively identified during 2015-2021. The APS phenotypes were described. A literature review of 8 previously reported cases was also included in analysis.

resultsA total of 8 patients (11%) (1 woman, 7 men; mean age: 52.4 ± 18.4 years) presented with APS in a cohort of 74 GFAP-IgG-positive patients, 3 of whom (4%) had disease onset with APS. All patients had hiccups, and hiccups was the unique symptom of APS in 5 patients. The median time from disease onset to APS occurrence was 2 days (range 0-20), and the mean duration of APS episodes was 23.6 ± 11.4 days. No patient had isolated APS attack. All episodes were completely resolved with a mean duration of 9.3 ± 5.4 days after immunotherapy. APS manifestations of 8 cases in previous studies showed similar features with our cases. In total, coexisting aquaporin-4-IgG was only detected in one of the 16 cases. DISCUSSION: APS could be an early, but not isolated clinical manifestation of autoimmune GFAP astrocytopathy. Hiccups was the predominant symptom of APS in this disorder. APS attacks of autoimmune GFAP astrocytopathy have good response to immunotherapy.

Indexed as

Area PostremaHiccupAquaporin 4AstrocytesGlial Fibrillary Acidic ProteinHumansImmunoglobulin GRetrospective StudiesSyndromeAquaporin 4GFAP protein, humanGlial Fibrillary Acidic ProteinImmunoglobulin G

Identifiers

PMID36163176
PMCPMC9513980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.