Evidence map›Paper›PMID 36163151›Full record

ArticleTranslational psychiatry2022

Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control.

Pei-Hsin Huang, Tsung-Ying Yang, Chia-Wei Yeh, Sheng-Min Huang, Ho-Ching Chang, Yun-Fen Hung, Wen-Chia Chu, Kuan-Hung Cho, Tzu-Pin Lu, Po-Hsiu Kuo and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Pei-Hsin HuangGraduate Institute of Pathology, College of Medicine, National Taiwan University, 100, Taipei, Taiwan. phhuang@ntu.edu.tw.ORCID 0000-0002-2414-1487
Tsung-Ying Yang *Graduate Institute of Pathology, College of Medicine, National Taiwan University, 100, Taipei, Taiwan.
Chia-Wei Yeh *Institute of Neuroscience, College of Life Sciences, National Yang Ming Chiao Tung University, 112, Taipei, Taiwan.ORCID 0000-0003-3486-3309
Sheng-Min Huang *Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 350, Miaoli, Taiwan.ORCID 0000-0003-2930-8562
Ho-Ching Chang *Institute of Molecular Biology, Academia Sinica, 115, Taipei, Taiwan.
Yun-Fen Hung *Institute of Molecular Biology, Academia Sinica, 115, Taipei, Taiwan.
Wen-Chia ChuGraduate Institute of Pathology, College of Medicine, National Taiwan University, 100, Taipei, Taiwan.
Kuan-Hung ChoInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 350, Miaoli, Taiwan.
Tzu-Pin LuDepartment of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, 100, Taipei, Taiwan.ORCID 0000-0003-3697-0386
Po-Hsiu KuoDepartment of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, 100, Taipei, Taiwan.ORCID 0000-0003-0365-3587
Li-Jen LeeGraduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 100, Taipei, Taiwan.ORCID 0000-0001-9108-3654
Li-Wei KuoInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 350, Miaoli, Taiwan.ORCID 0000-0002-0306-7329
Cheng-Chang LienInstitute of Neuroscience, College of Life Sciences, National Yang Ming Chiao Tung University, 112, Taipei, Taiwan.
Hwai-Jong ChengInstitute of Molecular Biology, Academia Sinica, 115, Taipei, Taiwan.
National Taiwan University · TWInstitute of Molecular Biology, Academia Sinica · TWNational Health Research Institutes · TWNational Yang Ming Chiao Tung University · TW

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

Mood disorders are an important public health issue and recent advances in genomic studies have indicated that molecules involved in neurodevelopment are causally related to mood disorders. BLM-s (BCL-2-like molecule, small transcript isoform), a BH3-only proapoptotic BCL-2 family member, mediates apoptosis of postmitotic immature neurons during embryonic cortical development, but its role in the adult brain is unknown. To better understand the physiological role of Blm-s gene in vivo, we generated a Blm-s-knockout (Blm-s

Indexed as

HippocampusNeurogenesisAdultAnimalsApoptosisDentate GyrusHumansMiceNeuronsProto-Oncogene Proteins c-bcl-2RecQ HelicasesBloom syndrome proteinProto-Oncogene Proteins c-bcl-2RecQ Helicases

Identifiers

PMID36163151
PMCPMC9512807
OpenAlexW4297237480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.