ReviewTrends in biochemical sciences2023
Determining and interpreting protein lifetimes in mammalian tissues.
Review in Trends in biochemical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Review
- A Computational Model for Determining Labeling Duration in Protein Turnover Studies Using a Single Deuterated Water Labeled Sample.Journal of the American Society for Mass Spectrometry · 2026Article
- Article
- Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Heat-shock pathway activation by TRC051384 protects spiral ganglion neurons from noise-induced hearing loss.bioRxiv : the preprint server for biology · 2025Article
- Turnover Rates and Numbers of Exchangeable Hydrogens in Deuterated Water Labeled Samples.International journal of molecular sciences · 2025Article
- Quantitative modeling of rod outer segment phagocytosis and recycling.Scientific reports · 2025Article
- Article
- Article
- Bioorthogonal Non-Canonical Amino Acid Tagging (BONCAT) to detect newly synthesized proteins in cells and their secretome.PloS one · 2025Article
- Disentangling protein metabolic costs in human cells and tissues.PNAS nexus · 2025Article
- Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan.eLife · 2024Article
- An Extensive Atlas of Proteome and Phosphoproteome Turnover Across Mouse Tissues and Brain Regions.bioRxiv : the preprint server for biology · 2024Article
- Numbers of Exchangeable Hydrogens from LC-MS Data of Heavy Water Metabolically Labeled Samples.Journal of the American Society for Mass Spectrometry · 2024Article
- Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases.iScience · 2024Article
- Derailed protein turnover in the aging mammalian brain.Molecular systems biology · 2024Article
- Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.Cell reports · 2023Article
- The cochlea is built to last a lifetime.Hearing research · 2023Review
- Article
- Quantifying label enrichment from two mass isotopomers increases proteome coverage for in vivo protein turnover using heavy water metabolic labeling.Communications chemistry · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The orchestration of protein production and degradation, and the regulation of protein lifetimes, play a central role in the majority of biological processes. Recent advances in proteomics have enabled the estimation of protein half-lives for thousands of proteins in vivo. What is the utility of these measurements, and how can they be leveraged to interpret the proteome changes occurring during development, aging, and disease? This opinion article summarizes leading technical approaches and highlights their strengths and weaknesses. We also disambiguate frequently used terminology, illustrate recent mechanistic insights, and provide guidance for interpreting and validating protein turnover measurements. Overall, protein lifetimes, coupled to estimates of protein levels, are essential for obtaining a deep understanding of mammalian biology and the basic processes defining life itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.