Trial reportLipids in health and disease2022
Replacing saturated fatty acids with polyunsaturated fatty acids increases the abundance of Lachnospiraceae and is associated with reduced total cholesterol levels-a randomized controlled trial in healthy individuals.
Trial report in Lipids in health and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03658681 (Fat Quality and Blood Glucose), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fat Quality and Blood Glucose
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Gut-Heart Axis: Effects of Intestinal Microbiome Modulation on Cardiovascular Disease-Ready for Therapeutic Interventions?International journal of molecular sciences · 2024Pooled it
- Lachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.Comprehensive reviews in food science and food safety · 2026Review
- The Adolescent Microbiome-Gut-Brain Axis: Development, Mechanisms, and Translational Perspectives.Nutrients · 2026Review
- Dietary and Supplementation Strategies for Modulating Gut Microbiota: A Narrative Review.Foods (Basel, Switzerland) · 2026Review
- Peripartum hypophosphatemia is associated with a hindgut-centered microbiota-metabolite-host axis in transition dairy cows.NPJ biofilms and microbiomes · 2026Article
- Gut Microbiome-Associated Effects of Plant-Based Diets on Glucose Homeostasis, Body Composition, and Cognitive Function: A Scoping Review.Advances in nutrition (Bethesda, Md.) · 2026Article
- Gut microbiota and parasite dynamics in an Amazonian community undergoing urbanization in Colombia.mSphere · 2026Article
- Ultra-processed Plant Foods: Are They Worse than their Unprocessed Animal-Based Counterparts?Current nutrition reports · 2025Review
- Effects of Diets with Different Energy Levels at Cold Temperatures on Gut Microbiota and Metabolic State in Growing-Finishing Pigs.Microorganisms · 2025Article
- Modulation of the Gut Microbiota byNutrients · 2025Article
- Gut Microbiota and Autism Spectrum Disorders: Neurodevelopmental, Behavioral, and Gastrointestinal Interactions.Nutrients · 2025Article
- Functional Foods for Cholesterol Management: A Review of the Mechanisms, Efficacy, and a Novel Cholesterol-Lowering Capacity Index.Nutrients · 2025Review
- Temporal Dynamics of Fecal Microbiome and Short-Chain Fatty Acids in Sows from Early Pregnancy to Weaning.Animals : an open access journal from MDPI · 2025Article
- Bovine colostrum-derived exosomes alleviate muscle degeneration by modulating gut microbiota and metabolic homeostasis in atrophy models.Journal of animal science and technology · 2025Article
- Dietary Intake and Gut Microbiome in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Associations of per- and polyfluoroalkyl substances with human milk metabolomic profiles in a rural North American cohort.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Mutual Interactions of Silymarin and Colon Microbiota in Healthy Young and Healthy Elder Subjects.Molecular nutrition & food research · 2024Article
- Assessment of the causal relationship between gut microbiota and cardiovascular diseases: a bidirectional Mendelian randomization analysis.BioData mining · 2024Article
- Endoscopic surgery affects the gut microbiota and its metabolism in breast cancer patients.Frontiers in microbiology · 2024Article
- Variations in the Relative Abundance of Gut Bacteria Correlate with Lipid Profiles in Healthy Adults.Microorganisms · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImproving dietary fat quality strongly affects serum cholesterol levels and hence the risk of cardiovascular diseases (CVDs). Recent studies have identified dietary fat as a potential modulator of the gut microbiota, a central regulator of host metabolism including lipid metabolism. We have previously shown a significant reduction in total cholesterol levels after replacing saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFAs). The aim of the present study was to investigate the effect of dietary fat quality on gut microbiota, short-chain fatty acids (SCFAs), and bile acids in healthy individuals. In addition, to investigate how changes in gut microbiota correlate with blood lipids, bile acids, and fatty acids.
methodsSeventeen participants completed a randomized, controlled dietary crossover study. The participants received products with SFAs (control) or PUFAs in random order for three days. Fecal samples for gut microbiota analyses and fasting blood samples (lipids, fatty acids, and bile acids) were measured before and after the three-day intervention.
resultsOf a panel of 40 bacteria, Lachnospiraceae and Bifidobacterium spp. were significantly increased after intervention with PUFAs compared with SFAs. Interestingly, changes in Lachnospiraceae, as well as Phascolarlactobacterium sp. and Eubacterium hallii, was also found to be negatively correlated with changes in total cholesterol levels after replacing the intake of SFAs with PUFAs for three days. No significant differences in SCFAs or bile acids were found after the intervention.
conclusionReplacing SFAs with PUFAs increased the abundance of the gut microbiota family of Lachnospiraceae and Bifidobacterium spp. Furthermore, the reduction in total cholesterol after improving dietary fat quality correlated with changes in the gut microbiota family Lachnospiraceae. Future studies are needed to reveal whether Lachnospiraceae may be targeted to reduce total cholesterol levels.
trial registrationThe study was registered at Clinical Trials ( https://clinicaltrials.gov/ , registration identification number: NCT03658681).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.