Evidence map›Paper›PMID 36163034›Full record

ArticleTrials2022

The SCRIPT trial: study protocol for a randomised controlled trial of a polygenic risk score to tailor colorectal cancer screening in primary care.

Sibel Saya, Lucy Boyd, Patty Chondros, Mairead McNamara, Michelle King, Shakira Milton, Richard De Abreu Lourenco, Malcolm Clark, George Fishman, Julie Marker and 9 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. GP perspectives on genomics in primary care: a qualitative study on using polygenic risk scores to evaluate cancer risk.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. 15 years of GWAS discovery: Realizing the promise.American journal of human genetics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Sibel SayaPrimary Care Cancer Research Group, Department of General Practice, Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Level 10, 305 Grattan Street, Melbourne, Victoria, 3000, Australia. sibel.saya@unimelb.edu.au.ORCID http://orcid.org/0000-0002-4796-6852
Lucy BoydPrimary Care Cancer Research Group, Department of General Practice, Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Level 10, 305 Grattan Street, Melbourne, Victoria, 3000, Australia.
Patty ChondrosPrimary Care Cancer Research Group, Department of General Practice, Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Level 10, 305 Grattan Street, Melbourne, Victoria, 3000, Australia.
Mairead McNamaraPrimary Care Cancer Research Group, Department of General Practice, Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Level 10, 305 Grattan Street, Melbourne, Victoria, 3000, Australia.
Michelle KingPrimary Care Cancer Research Group, Department of General Practice, Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Level 10, 305 Grattan Street, Melbourne, Victoria, 3000, Australia.
Shakira MiltonPrimary Care Cancer Research Group, Department of General Practice, Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Level 10, 305 Grattan Street, Melbourne, Victoria, 3000, Australia.
Richard De Abreu LourencoCentre for Health Economics Research and Evaluation, University of Technology Sydney, Sydney, Australia.
Malcolm ClarkIPN Medical Centres, Camberwell, Australia.
George FishmanConsumer Advisory Group, Primary Care Collaborative Cancer Clinical Trials Group, Carlton, Australia.
Julie MarkerConsumer Advisory Group, Primary Care Collaborative Cancer Clinical Trials Group, Carlton, Australia.
Cheri OstroffCentre for Workplace Excellence, University of South Australia, Adelaide, Australia.
Richard AllmanGenetic Technologies/Phenogen Sciences, Fitzroy, Australia.
Fiona M WalterPrimary Care Cancer Research Group, Department of General Practice, Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Level 10, 305 Grattan Street, Melbourne, Victoria, 3000, Australia.
Daniel BuchananCentre for Cancer Research, University of Melbourne, Melbourne, Australia.
Ingrid WinshipDepartment of Medicine, Melbourne Medical School, University of Melbourne, Melbourne, Australia.
Jennifer McIntoshPrimary Care Cancer Research Group, Department of General Practice, Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Level 10, 305 Grattan Street, Melbourne, Victoria, 3000, Australia.
Finlay MacraeDepartment of Medicine, Melbourne Medical School, University of Melbourne, Melbourne, Australia.
Mark JenkinsCentre for Cancer Research, University of Melbourne, Melbourne, Australia.
Jon EmeryPrimary Care Cancer Research Group, Department of General Practice, Centre for Cancer Research, The University of Melbourne, Victorian Comprehensive Cancer Centre, Level 10, 305 Grattan Street, Melbourne, Victoria, 3000, Australia.
The University of Melbourne · AUPrimary Care Collaborative Clinical Trials Group · AUThe Royal Melbourne Hospital · AUUniversity of South Australia · AUUniversity of Technology Sydney · AU

Funding

Cancer Australia 1183338
6 · The paper itself

Abstract

backgroundPolygenic risk scores (PRSs) can predict the risk of colorectal cancer (CRC) and target screening more precisely than current guidelines using age and family history alone. Primary care, as a far-reaching point of healthcare and routine provider of cancer screening and risk information, may be an ideal location for their widespread implementation.

methodsThis trial aims to determine whether the SCRIPT intervention results in more risk-appropriate CRC screening after 12 months in individuals attending general practice, compared with standard cancer risk reduction information. The SCRIPT intervention consists of a CRC PRS, tailored risk-specific screening recommendations and a risk report for participants and their GP, delivered in general practice. Patients aged between 45 and 70 inclusive, attending their GP, will be approached for participation. For those over 50, only those overdue for CRC screening will be eligible to participate. Two hundred and seventy-four participants will be randomised to the intervention or control arms, stratified by general practice, using a computer-generated allocation sequence. The primary outcome is risk-appropriate CRC screening after 12 months. For those in the intervention arm, risk-appropriate screening is defined using PRS-derived risk; for those in the control arm, it is defined using family history and national screening guidelines. Timing, type and results of the previous screening are considered in both arms. Objective health service data will capture screening behaviour. Secondary outcomes include cancer-specific worry, risk perception, predictors of CRC screening behaviour, screening intentions and health service use at 1, 6 and 12 months post-intervention delivery. DISCUSSION: This trial aims to determine whether a PRS-derived personalised CRC risk estimate delivered in primary care increases risk-appropriate CRC screening. A future population risk-stratified CRC screening programme could incorporate risk assessment within primary care while encouraging adherence to targeted screening recommendations.

trial registrationAustralian and New Zealand Clinical Trial Registry ACTRN12621000092897p. Registered on 1 February 2021.

Indexed as

Colorectal NeoplasmsEarly Detection of CancerAgedAustraliaHumansMass ScreeningMiddle AgedPrimary Health CareRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsCancer screeningClinical utility genomicsColorectal cancerFaecal occult Blood testGeneral practicePolygenic risk scorePrecision screeningPrimary careRisk-stratified screening

Identifiers

PMID36163034
PMCPMC9513012
OpenAlexW4297249157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.