Evidence map›Paper›PMID 36162961›Full record

ArticleComparative medicine2022

Effects of Early Antiretroviral Therapy on the Composition and Diversity of the Fecal Microbiome of SIV-infected Rhesus Macaques (

Tiffany R Lavinder, Devin N Fachko, Jeffrey Stanton, Benjamin Varco-Merth, Jeremy Smedley, Afam A Okoye, Rebecca L Skalsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comparative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tiffany R LavinderDivision of Comparative Medicine, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon;, Email: tlavinder@outlook.com.
Devin N FachkoVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon.
Jeffrey StantonDivision of Comparative Medicine, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon.
Benjamin Varco-MerthVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon.
Jeremy SmedleyVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon.
Afam A OkoyeVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon.
Rebecca L SkalskyVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon;, Email: skalsky@ohsu.edu.
Oregon Health & Science University · USOregon National Primate Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NIH HHS P51 OD011092
6 · The paper itself

Abstract

HIV-infected people develop reproducible disruptions in their gastrointestinal microbiota. Despite the suppression of HIV viremia via long-term antiretroviral therapy (ART), alterations still occur in gut microbial diversity and the commensal microbiota. Mounting evidence suggests these microbial changes lead to the development of gut dysbiosis-persistent inflammation that damages the gut mucosa-and correlate with various immune defects. In this study, we examined how early ART intervention influences microbial diversity in SIV-infected rhesus macaques. Using 16S rRNA sequencing, we defined the fecal microbiome in macaques given daily ART beginning on either 3 or 7 d after SIV infection (dpi) and characterized changes in composition, α diversity, and β diversity from before infection through 112 dpi. The dominant phyla in the fecal samples before infection were

Indexed as

HIV InfectionsMicrobiotaSimian Acquired Immunodeficiency SyndromeAnimalsAnti-Retroviral AgentsMacaca mulattaPhylogenyRNA, Ribosomal, 16SAnti-Retroviral AgentsRNA, Ribosomal, 16S

Identifiers

PMID36162961
PMCPMC9827599
OpenAlexW4297250831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.