Evidence map›Paper›PMID 36162870›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Persistent Antigen Harbored by Alveolar Macrophages Enhances the Maintenance of Lung-Resident Memory CD8

Jenna L Lobby, Ida Uddbäck, Christopher D Scharer, Tian Mi, Jeremy M Boss, Allan R Thomsen, Jan P Christensen, Jacob E Kohlmeier

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Good neighbors make lasting memory.Nature immunology · 2026
    Article
  3. HIF-1αImmunity · 2026
    Article
  4. T Cell Receptor Sharing in Hypersensitivity Pneumonitis.Computational and structural biotechnology journal · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. CD4Science advances · 2024
    Article
  9. Eosinophils promote CD8Signal transduction and targeted therapy · 2024
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jenna L LobbyDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA; and.ORCID 0000-0002-1395-2583
Ida UddbäckDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA; and.ORCID 0000-0001-6007-5918
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA; and.ORCID 0000-0001-7716-8504
Tian MiDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA; and.ORCID 0000-0002-6446-1995
Jeremy M BossDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA; and.ORCID 0000-0002-2432-1840
Allan R ThomsenDepartment of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2392-9803
Jan P ChristensenDepartment of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4299-9479
Jacob E KohlmeierDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA; and jkohlmeier@emory.edu.ORCID 0000-0002-7209-6641
Emory University · USUniversity of Copenhagen · DK

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Cellular and molecular programming of lung resident T cell memoryR35HL150803 · NHLBI · EMORY UNIVERSITY · PI JACOB E KOHLMEIER · 2020 to 2026
$5.4M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Multiscale modeling of influenza vaccination strategies for optimal T cell immunityU01HL139483 · NHLBI · EMORY UNIVERSITY · PI KOHLMEIER, JACOB E, ZARNITSYNA, VERONIKA I · 2018 to 2022
$3.5M
Regulation of lung TRM maintenance and the decline of pulmonary cellular immunityR01HL138508 · NHLBI · EMORY UNIVERSITY · PI KOHLMEIER, JACOB E · 2017 to 2019
$1.2M
Mechanisms of long-term maintenance of lung tissue-resident memory CD8 T cellsF31HL156639 · NHLBI · EMORY UNIVERSITY · PI LOBBY, JENNA L. · 2021 to 2022
$93k
NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS F31 HL156639NHLBI NIH HHS R01 HL138508NHLBI NIH HHS R35 HL150803NHLBI NIH HHS U01 HL139483NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Lung tissue-resident memory T cells are crucial mediators of cellular immunity against respiratory viruses; however, their gradual decline hinders the development of T cell-based vaccines against respiratory pathogens. Recently, studies using adenovirus (Ad)-based vaccine vectors have shown that the number of protective lung-resident CD8

Indexed as

Influenza, HumanInfluenza VaccinesAnimalsCD8-Positive T-LymphocytesHomeodomain ProteinsHumansImmunologic MemoryLungMacrophages, AlveolarMiceNerve Tissue ProteinsNucleoproteinsAdnp protein, mouseHomeodomain ProteinsInfluenza VaccinesNerve Tissue ProteinsNucleoproteins

Identifiers

PMID36162870
PMCPMC9588742
OpenAlexW4297250939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.