Evidence map›Paper›PMID 36162469›Full record

Observational studyEnvironmental research2023

Aerosol measurement identifies SARS-CoV 2 PCR positive adults compared with healthy controls.

Desireé Gutmann, Gerhard Scheuch, Timon Lehmkühler, Laura-Sabine Herrlich, Anton Landeis, Martin Hutter, Christoph Stephan, Maria Vehreschild, Yascha Khodamoradi, Ann-Kathrin Gossmann and 8 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Environmental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Desireé GutmannDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany. Electronic address: Desiree.Gutmann@kgu.de.
Gerhard ScheuchGS Bio-Inhalation GmbH, Headquarters & Logistics, Gemuenden, Germany.
Timon LehmkühlerDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Laura-Sabine HerrlichDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Anton LandeisDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Martin HutterDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Christoph StephanDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Maria VehreschildDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Yascha KhodamoradiDepartment of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Ann-Kathrin GossmannPalas GmbH, Partikel- und Lasermesstechnik, Greschbachstrasse 3b; 76229, Karlsruhe, Germany.
Florian KingPalas GmbH, Partikel- und Lasermesstechnik, Greschbachstrasse 3b; 76229, Karlsruhe, Germany.
Frederik WeisPalas GmbH, Partikel- und Lasermesstechnik, Greschbachstrasse 3b; 76229, Karlsruhe, Germany.
Maximilian WeissPalas GmbH, Partikel- und Lasermesstechnik, Greschbachstrasse 3b; 76229, Karlsruhe, Germany.
Holger F RabenauInstitute for Medical Virology, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Juergen GrafMedical Director, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Helena DonathDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Ralf SchubertDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Stefan ZielenDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, University Hospital Frankfurt, Goethe University, 60590, Frankfurt, Germany.
Goethe University Frankfurt · DEKarlsruhe University of Education · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSARS-CoV-2 is spread primarily through droplets and aerosols. Exhaled aerosols are generated in the upper airways through shear stress and in the lung periphery by 'reopening of collapsed airways'. Aerosol measuring may detect highly contagious individuals ("super spreaders or super-emitters") and discriminate between SARS-CoV-2 infected and non-infected individuals. This is the first study comparing exhaled aerosols in SARS-CoV-2 infected individuals and healthy controls.

designA prospective observational cohort study in 288 adults, comprising 64 patients testing positive by SARS CoV-2 PCR before enrollment, and 224 healthy adults testing negative (matched control sample) at the University Hospital Frankfurt, Germany, from February to June 2021. Study objective was to evaluate the concentration of exhaled aerosols during physiologic breathing in SARS-CoV-2 PCR-positive and -negative subjects. Secondary outcome measures included correlation of aerosol concentration to SARS-CoV-2 PCR results, change in aerosol concentration due to confounders, and correlation between clinical symptoms and aerosol.

resultsThere was a highly significant difference in respiratory aerosol concentrations between SARS-CoV-2 PCR-positive (median 1490.5/L) and -negative subjects (median 252.0/L; p < 0.0001). There were no significant differences due to age, sex, smoking status, or body mass index. ROC analysis showed an AUC of 0.8918.

conclusionsMeasurements of respiratory aerosols were significantly elevated in SARS-CoV-2 positive individuals, which helps to understand the spread and course of respiratory viral infections, as well as the detection of highly infectious individuals.

Indexed as

COVID-19SARS-CoV-2AdultHumansPolymerase Chain ReactionProspective StudiesRespiratory Aerosols and DropletsAcute respiratory tract infectionAerosolsCOVID-19PCRSuper spreader

Identifiers

PMID36162469
PMCPMC9507996
OpenAlexW4297179937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.