ArticleThe American journal of tropical medicine and hygiene2022
Etiologies of Acute Undifferentiated Febrile Illnesses in and near Iquitos from 1993 to 1999 in the Amazon River Basin of Peru.
Article in The American journal of tropical medicine and hygiene, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Pooled it
- Clinical presentation of Oropouche virus infection: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Pooled it
- (Re-)Emergence of Oropouche Virus (OROV) Infections: Systematic Review and Meta-Analysis of Observational Studies.Viruses · 2024Pooled it
- Transmission dynamics of Oropouche virus in Latin America and the Caribbean.Nature medicine · 2026Article
- Assessing the diagnostic performance of clinical, serological and molecular approaches to improve dengue case detection in the Peruvian Amazon.PLoS neglected tropical diseases · 2026Article
- Integrated surveillance of arboviruses in febrile patients from the Brazilian Amazon reveals complex co-circulation dynamics and hidden viral diversity.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- Sentinel surveillance of acute febrile illness in a Brazilian Amazon region: laboratory findings and epidemiological implications.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Risk factors for emerging, re-emerging, and newly recognized arboviruses and zoonotic viruses in Brazilian amazon.PLoS neglected tropical diseases · 2025Review
- Protein-based tools for the detection and characterisation of Oropouche virus infection.EMBO molecular medicine · 2025Article
- Venezuelan Equine Encephalitis, Peruvian Amazon, 2020.Emerging infectious diseases · 2025Article
- (Re)Emerging Arboviruses of Public Health Significance in the Brazilian Amazon.Microorganisms · 2025Review
- Arthropod-Borne and Rodent-Borne Infections in Peru From 1990 to 2022.The Journal of infectious diseases · 2025Article
- Leptospirosis-Improving Healthcare Outcomes for a Neglected Tropical Disease.Open forum infectious diseases · 2025Review
- Diagnosis and Clinical Description of Leptospirosis Cases Identified Through Hospital-Based Active Surveillance in Puerto Rico, 2019-2021.Journal of tropical medicine · 2025Article
- Genomic Epidemiology of 2023-2024 Oropouche Outbreak in Iquitos, Peru reveals independent origin from a concurrent outbreak in Brazil.medRxiv : the preprint server for health sciences · 2024Article
- Bacteriological and Serological Investigation of Leptospirosis in Dogs and Pigs in Palau.The American journal of tropical medicine and hygiene · 2024Article
- Article
- Leptospira spp. and Rickettsia spp. as pathogens with zoonotic potential causing acute undifferentiated febrile illness in a central-eastern region of Peru.BMC research notes · 2024Article
- Current challenges in the discovery of treatments against Mayaro fever.Expert opinion on therapeutic targets · 2024Review
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 2 countries.
Funding
Abstract
The objective of this study was to determine the etiology of febrile illnesses among patients from October 1, 1993 through September 30, 1999, in the urban community of Iquitos in the Amazon River Basin of Peru. Epidemiological and clinical data as well as blood samples were obtained from consenting patients at hospitals, health clinics and private residences. Samples were tested for arboviruses in cell cultures and for IgM and IgG antibodies by ELISA. Blood smears were examined for malaria, and sera were tested for antibodies to Leptospira spp. by ELISA and microscopic agglutination. Among 6,607 febrile patients studied, dengue viruses caused 14.6% of the cases, and Venezuelan equine encephalitis virus caused 2.5%, Oropouche virus 1.0%, Mayaro virus 0.4%, and other arboviruses caused 0.2% of the cases. Also, 22.9% of 4,844 patients tested were positive for malaria, and of 400 samples tested, 9% had evidence of acute leptospirosis. Although the study was not designed to assess the importance of these pathogens as a cause of human morbidity in the total population, these results indicate that arboviruses, leptospirosis, and malaria were the cause of approximately 50% of the febrile cases. Although the arboviruses that were diagnosed can produce asymptomatic infections, our findings increased the overall understanding of the relative health burden of these infections, as well as baseline knowledge needed for designing and implementing further studies to better assess the health impact and threat of these pathogens in the Amazon Basin of Peru.
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