ArticleProceedings of the National Academy of Sciences of the United States of America2022
Genetic adaptation of skin pigmentation in highland Tibetans.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 41 citations in OpenAlex.
- Stepwise allelic trajectory of ETP2 underlies trade-off between UVB tolerance and submergence adaptation in Arabidopsis thaliana.Nature communications · 2026Article
- Comparative analysis of serum vitamin D and haematological parameters among paediatric sickle cell and non-sickle cell patients at a teaching hospital in Accra, Ghana: a case-control study.BMC pediatrics · 2026Article
- Ancient Yellow River ancestry and divergent admixture histories in the Qiang people.Science advances · 2026Article
- Dark Skin Evolution in Early Humans: Revisiting the Skin Cancer Hypothesis Through Migration-Related Mismatch.Molecular biology and evolution · 2026Review
- Stem cell-derived extracellular vesicles for high-altitude skin injuries: pathological mechanisms, advanced Nano-delivery, and translational perspectives.Frontiers in bioengineering and biotechnology · 2026Review
- The genetic architecture of human skin pigmentation: evolution and adaptation across global populations.Frontiers in genetics · 2026Review
- Differentiating the demographic histories and local adaptations of middle-altitude Qiang and Tibetan people.Human genetics · 2025Article
- Structural Variations Associated with Adaptation and Coat Color in Qinghai-Tibetan Plateau Cattle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular Genetic Basis of Reproductive Fitness in Tibetan Sheep on the Qinghai-Tibet Plateau.Genes · 2025Article
- Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?Current issues in molecular biology · 2025Review
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- Whole methylomes reveal high-altitude-associated methylation at hypoxia and pigmentation genes in South American Indigenous populations.Environmental epigenetics · 2025Article
- Translation of Mutant Repetitive Genomic Sequences inInternational journal of molecular sciences · 2024Article
- [Progress in multiomics research on high altitude polycythemia].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Review
- Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep.Genomics, proteomics & bioinformatics · 2024Article
- Population genetic admixture and evolutionary history in the Shandong Peninsula inferred from integrative modern and ancient genomic resources.BMC genomics · 2024Article
- The peroxisome: an update on mysteries 3.0.Histochemistry and cell biology · 2024Review
- Whole Genome Resequencing Reveals Selection Signals Related to Wool Color in Sheep.Animals : an open access journal from MDPI · 2023Article
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Authors and funding
38 authors at 6 institutions in 1 country.
Zhaohui YangState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.ORCID 0000-0003-0958-4439
Caijuan BaiHigh Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China.
Youwei PuAcademy of Medical Science, Zhengzhou University, Zhengzhou 450052, China.ORCID 0000-0001-8163-976X
Qinghong KongGuizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical University, Zunyi 563000, China.ORCID 0000-0002-4503-7021
Yongbo GuoState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
OuzhuluobuHigh Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China.
GengdengNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining 810012, China.
Xuyang LiuYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Qi ZhaoYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Zhichao QiuYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Wangshan ZhengState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Yaoxi HeState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.ORCID 0000-0003-3324-3239
Yihan LinYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Lian DengState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China.
Chao ZhangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China.
Shuhua XuCenter for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China.ORCID 0000-0002-1975-1002
Yi PengState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Kun XiangState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Xiaoming ZhangState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
BaimayangjiHigh Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China.
CirenyangjiHigh Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China.
Chaoying CuiHigh Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China.
BaimakangzhuoHigh Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China.
GonggalanziHigh Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China.
BianbaHigh Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China.
Yongyue PanHigh Altitude Medical Research Center, School of Medicine, Tibetan University, Lhasa 850000, China.
Jingxue XinAcademy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China.
Yong WangAcademy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China.ORCID 0000-0003-0695-5273
Shiming LiuNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining 810012, China.
Liangbang WangNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining 810012, China.
Hengliang GuoSupercomputing Center of Henan Province, Zhengzhou University, Zhengzhou 450001, China.
Zhenzhen FengSchool of Geoscience and Technology, Zhengzhou University, Zhengzhou 450001, China.
Shaobo WangYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Hong ShiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Binghua JiangAcademy of Medical Science, Zhengzhou University, Zhengzhou 450052, China.
Tianyi WuNational Key Laboratory of High Altitude Medicine, Qinghai High Altitude Medical Research Institute, Xining 810012, China.
Xuebin QiState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.ORCID 0000-0002-7883-4983
Bing SuState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.ORCID 0000-0002-4379-9014
Kunming University of Science and Technology · CNKunming Institute of Zoology · CNChinese Academy of Sciences · CNZhengzhou University · CNTibetan Traditional Medical College · CNZunyi Medical University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strong ultraviolet (UV) radiation at high altitude imposes a serious selective pressure, which may induce skin pigmentation adaptation of indigenous populations. We conducted skin pigmentation phenotyping and genome-wide analysis of Tibetans in order to understand the underlying mechanism of adaptation to UV radiation. We observe that Tibetans have darker baseline skin color compared with lowland Han Chinese, as well as an improved tanning ability, suggesting a two-level adaptation to boost their melanin production. A genome-wide search for the responsible genes identifies
Indexed as
Adaptation, PhysiologicalAltitudeSkin PigmentationAcyltransferasesEthnicityHumansMelaninsPhenotypeTibetTranscriptomeUltraviolet RaysAcyltransferasesglycerone-phosphate O-acyltransferaseMelaninsadaptationhigh altitudepigmentationTibetanUV radiation
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