ArticleProceedings of the National Academy of Sciences of the United States of America2022
Neural signature of flexible coding in prefrontal cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Attentional selection drives information convergence within macaque lateral prefrontal cortex.PNAS nexus · 2026Article
- Human Beta Oscillations Reflect Magnitude and Fidelity of Priority Shifts in Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Insight and executive functions in acquired brain injury: empirical evidence and theoretical frameworks.Frontiers in neurology · 2026Review
- Domain general frontoparietal regions show modality-dependent coding of auditory and visual rules.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Is working memory domain-general or domain-specific?Trends in cognitive sciences · 2024Review
- Representation and computation in visual working memory.Nature human behaviour · 2024Review
- The prefrontal cortex: from monkey to man.Brain : a journal of neurology · 2024Review
- The synaptic correlates of serial position effects in sequential working memory.Frontiers in computational neuroscience · 2024Article
- Isometric Arm Forces Exerted by Females at Different Levels of Physical Comfort and Their EEG Signatures.Brain sciences · 2023Article
- Neural signature of flexible coding in prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
The ability of prefrontal cortex to quickly encode novel associations is crucial for adaptive behavior and central to working memory. Fast Hebbian changes in synaptic strength permit forming new associations, but neuronal signatures of this have been elusive. We devised a trialwise index of pattern similarity to look for rapid changes in population codes. Based on a computational model of working memory, we hypothesized that synaptic strength-and consequently, the tuning of neurons-could change if features of a subsequent stimulus need to be "reassociated," i.e., if bindings between features need to be broken to encode the new item. As a result, identical stimuli might elicit different neural responses. As predicted, neural response similarity dropped following rebinding, but only in prefrontal cortex. The history-dependent changes were expressed on top of traditional, fixed selectivity and were not explainable by carryover of previous firing into the current trial or by neural adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.