Evidence map›Paper›PMID 36161911›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Human sperm TMEM95 binds eggs and facilitates membrane fusion.

Shaogeng Tang, Yonggang Lu, Will M Skinner, Mrinmoy Sanyal, Polina V Lishko, Masahito Ikawa, Peter S Kim

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. The SPARK complex forms the molecular basis of vertebrate fertilization.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Membrane Fusions During Mammalian Fertilization.Advances in experimental medicine and biology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Non-Hormonal Contraception.Journal of clinical medicine · 2023
    Review
  14. Review
  15. 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Human sperm TMEM95 binds eggs and facilitates membrane fusion.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Shaogeng TangDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-3904-492X
Yonggang LuImmunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0003-0198-8906
Will M SkinnerEndocrinology Graduate Group, University of California, Berkeley, Berkeley, CA 94720.ORCID 0000-0002-2383-4003
Mrinmoy SanyalDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-1365-4279
Polina V LishkoDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720.ORCID 0000-0003-3140-2769
Masahito IkawaImmunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0001-9859-6217
Peter S KimDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-6503-4541
Stanford University · USBuck Institute for Research on Aging · USChan Zuckerberg Initiative (United States) · USSystems Biology Institute · JPThe University of Osaka · JPUniversity of California, Berkeley · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Thomas Michael Weiss · 2020 to 2026
$43.3M
Cell Surface Receptor Recognition and Membrane Fusion in Mammalian FertilizationK99HD104924 · NICHD · STANFORD UNIVERSITY · PI TANG, SHAOGENG · 2021 to 2022
$383k
NICHD NIH HHS K99 HD104924NIGMS NIH HHS P30 GM133894
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Infertility, MaleMembrane FusionMembrane ProteinsOvumSeminal Plasma ProteinsSpermatozoaSperm-Ovum InteractionsAmino Acid SubstitutionAnimalsAntibodies, MonoclonalCricetinaeHumansMaleSemenAntibodies, MonoclonalMembrane ProteinsSeminal Plasma Proteinsfertilizationmembrane fusionsperm–egg fusionTMEM95

Identifiers

PMID36161911
PMCPMC9546558
OpenAlexW4297093972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.