Evidence map›Paper›PMID 36161903›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Reduced Satb1 expression predisposes CD4

Pawan K Gupta, Jennifer B Allocco, Jane M Fraipont, Michelle L McKeague, Peter Wang, Michael S Andrade, Christine McIntosh, Luqiu Chen, Ying Wang, Yan Li and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 7 citations in OpenAlex.

  1. SATB1 preserves CD4Life science alliance · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Polysaccharides derived from alkali-extracted vinegar-bakedJournal of traditional and complementary medicine · 2025
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Pawan K GuptaSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637.
Jennifer B AlloccoSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-1498-0543
Jane M FraipontSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-5875-7175
Michelle L McKeagueSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637.
Peter WangSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637.ORCID 0000-0001-7790-2596
Michael S AndradeSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-1404-3015
Christine McIntoshSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637.
Luqiu ChenSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637.
Ying WangSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-8867-9884
Yan LiCenter for Research Informatics, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-9481-8086
Jorge AndradeCenter for Research Informatics, University of Chicago, Chicago, IL 60637.
José R Conejo-GarciaDepartment of Immunology, Moffitt Cancer Center & Research Institute, University of South Florida, Tampa, FL 33612.
Anita S ChongSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL 60637.
Maria-Luisa AlegreSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637.ORCID 0000-0001-5707-6194
University of Chicago · USUniversity of South Florida · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)T32HD007009 · NICHD · UNIVERSITY OF CHICAGO · PI NANCY B SCHWARTZ · 1985 to 2026
$13.0M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
Targetable epigenetic mechanism driving Cutaneous T cell LymphomaR01CA240434 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI CONEJO-GARCIA, JOSE R, PINILLA, JAVIER · 2019 to 2023
$2.6M
NCI NIH HHS R01 CA240434NIAID NIH HHS T32 AI007090NICHD NIH HHS T32 HD007009NIDDK NIH HHS P30 DK042086
6 · The paper itself

Abstract

Limiting CD4

Indexed as

Graft SurvivalMatrix Attachment Region Binding ProteinsT-Lymphocytes, RegulatoryTranscription FactorsTransplantation ToleranceAnimalsImmunologic MemoryInterleukin-2MiceMice, Inbred C57BLInterleukin-2Matrix Attachment Region Binding ProteinsSatb1 protein, mouseTranscription FactorsSatb1T cell dysfunctiontransplantationTreg suppression

Identifiers

PMID36161903
PMCPMC9546564
OpenAlexW4297092867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.