Evidence map›Paper›PMID 36161884›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses.

Christopher M Uyehara, Mary Leatham-Jensen, Daniel J McKay

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  5. Optogenetic control of transition to metamorphosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. bioRxiv : the preprint server for biology · 2025
    Article
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  8. Article
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  11. A hormone-to-neuropeptide pathway inhibits sexual receptivity in immatureProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Genes & development · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. SetDB1 and Su(var)3-9 are essential for late stages of larval development of Drosophila melanogaster.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023
    Article
  17. Article
  18. Article
  19. Coregulators Reside withinInternational journal of molecular sciences · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christopher M UyeharaDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Mary Leatham-JensenDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0002-6416-021X
Daniel J McKayDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0001-8226-0604
University of North Carolina at Chapel Hill · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
NIGMS NIH HHS R35 GM128851NIGMS NIH HHS T32 GM007092NIH HHS P40 OD018537
6 · The paper itself

Abstract

Steroid hormones perform diverse biological functions in developing and adult animals. However, the mechanistic basis for their tissue specificity remains unclear. In

Indexed as

ChromatinDrosophila melanogasterDrosophila ProteinsEcdysoneEnhancer Elements, GeneticGene Expression RegulationReceptors, SteroidAnimalsDNALigandsChromatinDNADrosophila ProteinsEcdysoneecdysone receptorLigandsReceptors, Steroidchromatin accessibilityhormonenuclear receptor

Identifiers

PMID36161884
PMCPMC9546573
OpenAlexW4297092788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.