ArticleObesity (Silver Spring, Md.)2022
Plasma metabolomic signatures of obesity and risk of type 2 diabetes.
Article in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Temporal changes in circulating metabolites after metabolic and bariatric surgery and risk of incident coronary heart disease: evidence from prospective cohort and nested case-control studies.International journal of surgery (London, England) · 2026Article
- Preparation, Structural Characterization, and Synergistic Hypoglycemic Effect of Jujube Polysaccharide-Polyphenol Complex.Foods (Basel, Switzerland) · 2026Article
- Short-term and long-term high-fat diet promote metabolic disorder through reprogramming mRNA mMicrobiome · 2025Article
- In-depth multiomic characterization of the effects of obesity in high-fat diet-fed mice.FEBS open bio · 2024Article
- Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies.Med (New York, N.Y.) · 2024Article
- Metabolomic signature between diabetic and non-diabetic obese patients: A protocol for systematic review.PloS one · 2024Article
- Metabolite Signature of Life's Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans.Circulation. Genomic and precision medicine · 2023Article
- Review
- Metabolomic phenotyping of obesity for profiling cardiovascular and ocular diseases.Journal of translational medicine · 2023Article
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveThe mechanisms linking obesity to type 2 diabetes (T2D) are not fully understood. This study aimed to identify obesity-related metabolomic signatures (MESs) and evaluated their relationships with incident T2D.
methodsIn a nested case-control study of 2076 Chinese adults, 140 plasma metabolites were measured at baseline, linear regression was applied with the least absolute shrinkage and selection operator to identify MESs for BMI and waist circumference (WC), and conditional logistic regression was applied to examine their associations with T2D risk.
resultsA total of 32 metabolites associated with BMI or WC were identified and validated, among which 14 showed positive associations and 3 showed inverse associations with T2D; 8 and 18 metabolites were selected to build MESs for BMI and WC, respectively. Both MESs showed strong linear associations with T2D: odds ratio (95% CI) comparing extreme quartiles was 4.26 (2.00-9.06) for BMI MES and 9.60 (4.22-21.88) for WC MES (both p-trend < 0.001). The MES-T2D associations were particularly evident among individuals with normal WC: odds ratio (95% CI) reached 6.41 (4.11-9.98) for BMI MES and 10.38 (6.36-16.94) for WC MES. Adding MESs to traditional risk factors and plasma glucose improved C statistics from 0.79 to 0.83 (p < 0.001).
conclusionsMultiple obesity-related metabolites and MESs strongly associated with T2D in Chinese adults were identified.
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