ArticlePediatric obesity2023
Circadian variation of serum leptin and adipose tissue changes in children.
Article in Pediatric obesity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 0 citations in OpenAlex.
- Leptin Associates with Circadian Light Hygiene and REV-ERBα in Arctic Residents.Bulletin of experimental biology and medicine · 2026Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHigher morning serum leptin values are associated with larger adipose tissue gains in children; however, it is unclear if leptin circadian variation is itself associated with adipose tissue changes during growth.
objectiveWe studied the association of circadian variation in leptin with change in total body fat mass (TBFM), total body percentage fat (%FM), and trunk fat mass (TrFM).
methodsBaseline serum samples for leptin were obtained every 3 h for 24 h from 130 children (baseline age 9.6 ± 2.5y; 51.1% male; BMI-Z 1.59) with mean follow-up of 11.1 ± 4.0y and underwent dual-energy x-ray absorptiometry. ANCOVA models examined change in TBFM, %FM, or TrFM as dependent variables and number of years of follow-up, sex, race, baseline age, pubertal status, initial visit body composition, and initial visit serum leptin circadian variables (maximal diurnal leptin [acrophase], diurnal amplitude, and percentage change of amplitude) as independent factors.
resultAlthough initial visit mesor (24 h average) leptin was positively associated with initial visit TBFM (r
conclusionWe found no evidence that circadian variation in serum leptin concentrations during childhood is associated with long-term changes in children's adiposity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.