Evidence map›Paper›PMID 36161668›Full record

ArticleMagnetic resonance in medicine2023

Free-breathing 3D CEST MRI of human liver at 3.0 T.

Pei Han, Karandeep Cheema, Tianle Cao, Hsu-Lei Lee, Fei Han, Nan Wang, Hui Han, Yibin Xie, Anthony G Christodoulou, Debiao Li

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Human liver CEST imaging at 7 T: Impact ofMagnetic resonance in medicine · 2025
    Article
  4. MRI of GlycoNOE in the human liver using GraspNOE-Dixon.Magnetic resonance in medicine · 2025
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Pei HanBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0001-8532-9339
Karandeep CheemaBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Tianle CaoBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0003-3739-3103
Hsu-Lei LeeBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Fei HanSiemens Healthineers, Los Angeles, California, USA.
Nan WangDepartment of Radiology, Stanford University, Stanford, California, USA.ORCID 0000-0002-7616-8083
Hui HanBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Yibin XieBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Anthony G ChristodoulouBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-9334-8684
Debiao LiBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Cedars-Sinai Medical Center · USSiemens Healthcare (United States) · USStanford University · US

Funding

Quantitative Multiparametric MRI to Assess the Effect of Stem Cell Therapy on Chronic Low Back PainR01AR066517 · NIAMS · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2014 to 2024
$5.3M
Motion-Resolved, Comprehensive Quantitative Tissue Characterization Using MR MultitaskingR01EB028146 · NIBIB · CEDARS-SINAI MEDICAL CENTER · PI CHRISTODOULOU, ANTHONY G, LI, DEBIAO · 2019 to 2022
$2.5M
SSFP Cardiovascular MR Imaging on 3.0T Using Unified-Coil Local ShimmingR01HL156818 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SPINCEMAILLE, PASCAL, YANG, HSIN-JUNG · 2021 to 2024
$2.5M
NHLBI NIH HHS R01 HL156818NIAMS NIH HHS R01 AR066517NIBIB NIH HHS R01 EB028146
6 · The paper itself

Abstract

purposeTo develop a novel 3D abdominal CEST MRI technique at 3 T using MR multitasking, which enables entire-liver coverage with free-breathing acquisition.

methodsk-Space data were continuously acquired with repetitive steady-state CEST (ss-CEST) modules. The stack-of-stars acquisition pattern was used for k-space sampling. MR multitasking was used to reconstruct motion-resolved 3D CEST images of 53 frequency offsets with entire-liver coverage and 2.0 × 2.0 × 6.0 mm

resultsBoth APT-CEST and glycoCEST signals showed high sensitivity between post-fasting and post-meal acquisitions. APT-CEST and glycoCEST MTRasym signals from post-mean scans were significantly increased (APT-CEST: -0.019 ± 0.017 in post-fasting scans, 0.014 ± 0.021 in post-meal scans, p < 0.01; glycoCEST: 0.003 ± 0.009 in post-fasting scans, 0.027 ± 0.021 in post-meal scans, p < 0.01).

conclusionThe proposed 3D abdominal steady-state CEST method using MR multitasking can generate CEST images of the entire liver during free breathing.

Indexed as

Magnetic Resonance ImagingProtonsAmidesDimapritHumansImaging, Three-DimensionalLiverAmidesAPTDimapritProtonsAPTchemical exchange saturation transferglycogenliverMR multitaskingsteady-state CEST

Identifiers

PMID36161668
PMCPMC9712251
OpenAlexW4297229480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.