Evidence map›Paper›PMID 36161592›Full record

ArticleTurkish journal of medical sciences2022

Investigation of the expression levels of CDH1, FHIT, PTEN, and TTPAL genes in colorectal tumors.

Evrim Suna Suna Arıkan Söylemez, Zafer Söylemez, Murat Çilekar, Yüksel Arıkan, Çiğdem Tokyol, İbrahim Halil Kenger, Mustafa Solak

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Turkish journal of medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Evrim Suna Suna Arıkan SöylemezDepartment of Medical Biology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Zafer SöylemezDepartment of Medical Biology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Murat ÇilekarDepartment of General Surgery, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Yüksel ArıkanGeneral Surgery Department, Park Hayat Hospital, Afyonkarahisar, Turkey.
Çiğdem TokyolDepartment of Pathology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
İbrahim Halil KengerDepartment of Medical Genetics, Faculty of Medicine, Gaziantep Islam, Science and Technology University, Gaziantep, Turkey.
Mustafa SolakDepartment of Medical Genetics, Faculty of Medicine, Biruni University, İstanbul, Turkey.
Afyon Kocatepe University · TRAfyonkarahisar Sağlık Bilimleri Üniversitesi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe main aim of the study is to assess expression levels of CDH1, FHIT, PTEN, and TTPAL genes in tumors and peripheral bloods of colorectal cancer patients in staged I-IV.

methodsGene expression analysis of related genes were performed for tumor tissues and peripheral blood samples of 51 colorectal cancer patients and colon tissues and blood samples of 5 healthy individuals. The real-time-PCR reaction method was used for the analysis.

resultsAlteration of mRNA levels of related genes in tumor tissues of colorectal cancer cases was determined compared to control tissues. GAPDH and TBP were used for the normalization. While the mRNA levels of CDH1 decreased, the mRNA level of the FHIT and TTPAL genes increased in the tumor tissues. There was no PTEN gene expression difference in tumor tissues (total). The mRNA levels of the CDH1 and PTEN genes were increased while the mRNA levels of FHIT and TTPAL genes decreased in the blood (total). T he mRNA levels of the CDH1 gene decreased at each stage (I-IV) in the tumor tissues and increased at each stage (I-IV) in the blood. T he PTEN gene mRNA levels at each stage were controversial. The mRNA levels of the FHIT gene increased at stage I-II-III, decreased at stage IV in the tissues and decreased at each stage (I-IV) in the blood. The mRNA levels of TTPAL gene increased at each stage (I-IV) in the tissues and decreased at each stage (I-IV) in the blood.

Indexed as

Acid Anhydride HydrolasesColorectal NeoplasmsAntigens, CDBis(5'-adenosyl)triphosphataseCadherinsHumansNeoplasm ProteinsPTEN PhosphohydrolaseRNA, MessengerAcid Anhydride HydrolasesAntigens, CDBis(5'-adenosyl)triphosphataseCadherinsCDH1 protein, humanNeoplasm ProteinsPTEN PhosphohydrolasePTEN protein, humanRNA, MessengerCDH1colorectal tumorFHITgene expressionPTENTTPAL

Identifiers

PMID36161592
PMCPMC10734844
OpenAlexW4205152950

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.