ArticleDocumenta ophthalmologica. Advances in ophthalmology2022
Structure-function models for estimating retinal ganglion cell count using steady-state pattern electroretinography and optical coherence tomography in glaucoma suspects and preperimetric glaucoma: an electrophysiological pilot study.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 12 citations in OpenAlex.
- Foveal Avascular Zone Enlargement as a Risk Factor for Early Retinal Ganglion Cell Dysfunction in Glaucoma Suspects.Diagnostics (Basel, Switzerland) · 2025Article
- Novel Structure-Function Models for Estimating Retinal Ganglion Cell Count Using Pattern Electroretinography in Glaucoma Suspects.Diagnostics (Basel, Switzerland) · 2025Article
- Retinal Vessel Diameter Reductions Are Associated with Retinal Ganglion Cell Dysfunction, Thinning of the Ganglion Cell and Inner Plexiform Layers, and Decreased Visual Field Global Indices in Glaucoma Suspects.Diagnostics (Basel, Switzerland) · 2025Article
- Diagnostic Capability of Pattern Electroretinogram and Three Circumpapillary Retinal Nerve Fiber Layer Thickness Circle Diameter Scans in Glaucoma Suspects.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Resveratrol protects against diabetic retinal ganglion cell damage by activating the Nrf2 signaling pathway.Heliyon · 2024Article
- Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma Suspects.Journal of ophthalmology · 2024Article
- Posterior Pole Asymmetry Analysis as a Diagnostic Tool in Glaucoma Suspects: An Electrophysiological Approach.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- The Discriminatory Ability of Ganglion Cell Inner Plexiform Layer Complex Thickness in Patients with Preperimetric Glaucoma.Journal of current ophthalmologyArticle
- Retinal Ganglion Cell Functional Recovery after Intraocular Pressure Lowering Treatment Using Prostaglandin Analogs in Glaucoma Suspects: A Prospective Pilot Study.Journal of current glaucoma practiceArticle
- Pattern Electroretinogram in Glaucoma Suspects with Signs of Conversion: Diagnosis, Assessment, and Monitoring Treatment - Case Report.Case reports in ophthalmologyArticle
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo derive and validate structure-function models for estimating retinal ganglion cell (RGC) count using optical coherence tomography (OCT) and steady-state pattern electroretinography (ssPERG) parameters in glaucoma suspects (GS) and preperimetric glaucoma (PPG).
methodsIn this prospective cross-sectional study, 25 subjects (50 eyes) were recruited at the Manhattan Eye, Ear, and Throat Hospital. Subjects underwent comprehensive eye examinations, OCT, standard automated perimetry (SAP), and ssPERG testing. Eyes were divided into three groups based on the Global Glaucoma Staging System: healthy (N = 30), GS (N = 10), and PPG (N = 10) eyes. The combined structure-function index (CSFI), which estimates retinal ganglion cell count (eRGC
resultsThe ARNFLT, ssPERG parameters magnitude (Mag) and magnitudeD (MagD), and eRGC
conclusionThis pilot study offers the first combined structure-function models for estimating RGC count using ssPERG parameters. RGC counts estimated with these models were generalizable, strongly associated with CSFI estimates, and performed better than individual ssPERG and OCT measures in distinguishing healthy, GS, and PPG eyes.
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