ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Mechanically Robust Hydrogels Facilitating Bone Regeneration through Epigenetic Modulation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
- Immune-epigenetic convergence in biomaterial-guided tissue regeneration.Materials today. Bio · 2026Article
- POSS-PEG-NHS and GSH Cocrosslink DPAV to Prepare Anticalcification Bioprosthetic Scaffold With Enhanced Reendothelization, Anti-inflammation, and Anti-ROS.Advanced healthcare materials · 2026Article
- Design and Therapeutic Applications of Hydrogel Dressings in Diverse Wound Management.ACS omega · 2026Review
- Smart Hydrogels for Craniofacial Regeneration.Cells · 2026Review
- Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine.MedComm · 2026Review
- Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Hydrogel-based strategies for periprosthetic joint infection: from osteoimmune mechanisms to clinical translation.Frontiers in cell and developmental biology · 2026Review
- A review on thermoresponsive PNIPAM hydrogels for regenerative medicine: from mechanical design to tissue adhesion.Regenerative biomaterials · 2026Review
- The injectable cationic double-crosslinked hydrogel facilitates bone regeneration and repair through sustained antibacterial activity.Materials today. Bio · 2025Article
- Hydrogel-Based Delivery Systems for Non-Opioid Analgesics: Advances, Challenges, and Clinical Prospects.Journal of clinical medicine · 2025Review
- Hydrogel-Based Therapeutic Strategies for Periodontal Tissue Regeneration: Advances, Challenges, and Future Perspectives.Pharmaceutics · 2025Review
- End-tail soaking strategy toward robust and biomimetic sandwich-layered hydrogels for full-thickness bone regeneration.Bioactive materials · 2025Article
- POSS-based hybrid biomaterials for tissue engineering and regenerative medicine.Materials today. Bio · 2025Review
- ROS-Activated Nanohydrogel Scaffolds with Multi-Factors Controlled Release for Targeted Dual-Lineage Repair of Osteochondral Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Application of hydrogel-loaded dental stem cells in the field of tissue regeneration.Human cell · 2024Review
- Circ_0003764 Regulates the Osteogenic Differentiation of Periodontal Ligament Stem Cells.International dental journal · 2024Article
- Biomaterial Scaffolds for Periodontal Tissue Engineering.Journal of functional biomaterials · 2024Review
- Matrix Metalloproteinase-Responsive Hydrogel with On-Demand Release of Phosphatidylserine Promotes Bone Regeneration Through Immunomodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Injectable ultrasound-powered bone-adhesive nanocomposite hydrogel for electrically accelerated irregular bone defect healing.Journal of nanobiotechnology · 2024Article
- Mechanical force increases tooth movement and promotes remodeling of alveolar bone defects augmented with bovine bone mineral.Progress in orthodontics · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Development of artificial biomaterials by mimicking extracellular matrix of bone tissue is a promising strategy for bone regeneration. Hydrogel has emerged as a type of viable substitute, but its inhomogeneous networks and weak mechanics greatly impede clinical applications. Here, a dual crosslinked gelling system is developed with tunable architectures and mechanics to promote osteogenic capacity. Polyhedral oligomeric silsesquioxane (POSS) is designated as a rigid core surrounded by six disulfide-linked PEG shells and two 2-ureido-4[1H]-pyrimidinone (UPy) groups. Thiol-disulfide exchange is employed to fabricate chemical network because of the pH-responsive "on/off" function. While self-complementary UPy motif is capable of optimizing local microstructure to enhance mechanical properties. Taking the merits of biocompatibility and high-mechanics in periodontal ligament stem cells (PDLSCs) proliferation, attachment, and osteogenesis, hybrid hydrogel exhibits outstanding osteogenic potential both in vitro and in vivo. Importantly, it is the first time that a key epigenetic regulator of ten-eleven translocation 2 (Tet2) is discovered to significantly elevate the continuously active the WNT/β-catenin through Tet2/HDAC1/E-cadherin/β-catenin signaling cascade, thereby promoting PDLSCs osteogenesis. This work represents a general strategy to design the hydrogels with customized networks and biomimetic mechanics, and illustrates underlying osteogenic mechanisms that will extend the design rationales for high-functional biomaterials in tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.