Evidence map›Paper›PMID 36161274›Full record

ArticleChemMedChem2022

Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives.

Eddy E Alfonso, Rogelio Troche, Zifang Deng, Thirunavukkarasu Annamalai, Prem Chapagain, Yuk-Ching Tse-Dinh, Fenfei Leng

Open access · greenAbstract read
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Eddy E AlfonsoBiomolecular Sciences Institute, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
Rogelio TrocheBiomolecular Sciences Institute, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
Zifang DengBiomolecular Sciences Institute, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
Thirunavukkarasu AnnamalaiBiomolecular Sciences Institute, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
Prem ChapagainBiomolecular Sciences Institute, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.ORCID 0000-0002-0999-4975
Yuk-Ching Tse-DinhBiomolecular Sciences Institute, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
Fenfei LengBiomolecular Sciences Institute, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.ORCID 0000-0002-9024-1216
Florida International University · US

Funding

Targeting transcription-coupled DNA supercoiling for discovering antibiotics against bacterial DNA gyraseR21AI125973 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LENG, FENFEI · 2017 to 2018
$478k
NIAID NIH HHS R21 AI125973
6 · The paper itself

Abstract

Bacterial DNA gyrase, an essential enzyme, is a validated target for discovering and developing new antibiotics. Here we screened a pool of polyphenols and discovered that digallic acid is a potent DNA gyrase inhibitor. We also found that several food additives based on gallate, such as dodecyl gallate, potently inhibit bacterial DNA gyrase. Interestingly, the IC

Indexed as

DNA GyraseMethicillin-Resistant Staphylococcus aureusDepsidesDNA, BacterialEscherichia coliGallic AcidTopoisomerase II InhibitorsDepsidesdigallic acidDNA, BacterialDNA GyraseGallic AcidTopoisomerase II Inhibitorsbacterial DNA gyrasedigallic acidDNA topoisomerasegallate derivativespolyphenols

Identifiers

PMID36161274
PMCPMC9742164
OpenAlexW4297242772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.