Evidence map›Paper›PMID 36161199›Full record

ArticleChronic diseases and translational medicine2022

Altered asymmetries of resting-state MRI in the left thalamus of first-episode schizophrenia.

Sha Liu, Zhenglong Guo, Hongbao Cao, Hong Li, Xiaodong Hu, Long Cheng, Jianying Li, Ruize Liu, Yong Xu

Abstract read
In one paragraph

Article in Chronic diseases and translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sha LiuDepartment of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan Shanxi China.
Zhenglong GuoDepartment of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan Shanxi China.
Hongbao CaoSchool of Systems Biology George Mason University Manassas Virginia USA.
Hong LiDepartment of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan Shanxi China.
Xiaodong HuDepartment of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan Shanxi China.
Long ChengDepartment of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan Shanxi China.
Jianying LiDepartment of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan Shanxi China.
Ruize LiuStanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts USA.
Yong XuDepartment of Psychiatry First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan Shanxi China.ORCID 0000-0002-6710-8126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Schizophrenia (SCZ) is a complex psychiatric disorder associated with widespread alterations in the subcortical brain structure. Hemispheric asymmetries are a fundamental organizational principle of the human brain and relate to human psychological and behavioral characteristics. We aimed to explore the state of thalamic lateralization of SCZ. Methods: We used voxel-based morphometry (VBM) analysis, whole-brain analysis of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and resting-state seed-based functional connectivity (FC) analysis to investigate brain structural and functional deficits in SCZ. Also, we applied Pearson's correlation analysis to validate the correlation between Positive and Negative Symptom Scale (PANSS) scores and them. Results: Compared with healthy controls, SCZ showed increased gray matter volume (GMV) of the left thalamus ( Conclusions: Collectively, these results suggest the possibility of aberrant laterality in the left thalamus and its FC with other related brain regions involved in the limbic system.

Indexed as

asymmetrygray matter volumeresting‐state fMRIschizophreniathalamus

Identifiers

PMID36161199
PMCPMC9481880

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.