ArticlePreventive medicine reports2022
Triglyceride glucose index: A new biomarker in predicting cardiovascular risk.
Article in Preventive medicine reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effect of exercise intervention on the triglyceride-glucose (TyG) index in adolescents with overweight or obesity: a systematic review and Bayesian dose-response meta-analysis.BMC pediatrics · 2025Pooled it
- Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis.Cardiovascular diabetology · 2024Pooled it
- Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial.Nature communications · 2026Trial
- Exploring the impact of metabolic comorbidities on epicardial adipose tissue in heart failure with preserved ejection fraction.Cardiovascular diabetology · 2025Trial
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- Trial
- Association of Serum Lithium Levels with Insulin Resistance in Type-2 Diabetes Patients.Biological trace element research · 2026Article
- Article
- Metabolic dysfunction and insulin resistance across major dementias: A comprehensive narrative review of the TyG index as a predictive marker.Metabolism open · 2026Review
- Associations between serum per- and polyfluoroalkyl substance concentrations and β-cell function and insulin resistance in adult females.The Journal of clinical endocrinology and metabolism · 2026Article
- Reduced Cardiovascular Risk Indicated by Changes in Triglyceride-Glucose Index After Pancreas Transplantation.Annals of transplantation · 2026Article
- Coronary Microvascular Dysfunction and Lipid Molecules: Pathophysiological Mechanisms, Clinical Assessment, and Therapeutic Implications.Journal of personalized medicine · 2026Review
- Nonlinear Association of the Triglyceride-Glucose Index With Hyperuricemia Among Young Chinese Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Triglyceride Glucose Index as a screening tool for subclinical heart failure with preserved ejection fraction in type 2 diabetes mellitus in resource-limited settings.Journal of family medicine and primary care · 2026Article
- Long-term prognosis of coexistent metabolic dysfunction-associated steatotic liver disease and chronic kidney disease following acute myocardial infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Age-Dependent Lipid-Cardiovascular Interplay in Patients at High and Very High Cardiovascular Risk.Journal of clinical medicine · 2026Article
- Clinical Use of the Triglycerides/Glucose (TyG) Index in the Early Assessment of Metabolic Alterations and Cardiovascular Remodeling in Essential Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- The Role of the Triglyceride-Glucose Index and Other Prognostic Factors in Predicting Coronary Slow Flow.Journal of cardiovascular development and disease · 2026Article
- Comparison of the correlation between triglyceride-glucose index and homeostasis model assessment of insulin resistance with subclinical left ventricular dysfunction.Journal of diabetes investigation · 2026Article
- Association Between Stress Hyperglycemia Ratio and Coronary Slow Flow Phenomenon in Patients with MINOCA.International journal of general medicine · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Insulin resistance can be assessed by the Triglyceride-Glucose Index (TyG), a simple, low-cost, and easy-to-apply method. Objective: To assess the predictive capacity of the TyG index about cardiovascular risk and identify its cutoff point in a population at cardiometabolic risk. Methods: Cross-sectional study with 264 individuals at cardiometabolic risk (54.9% women, age: 43.1 ± 16.3 years). Demographic, anthropometric, clinical-laboratory, and lifestyle data were collected. The TyG index was determined using the formula Ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg (dL)/2]. The ten-year cardiovascular risk was assessed by the Framingham risk score (FRS). The receiver operating characteristic curve (ROC) was used to define the cutoff point for the TyG index, and the associations were tested by Poisson regression. Results: ROC curve analysis indicated an area under the curve of 0.678 (95% CI = 0.618-0.734; p < 0.001), with a cutoff of 9.04 (sensitivity = 62.5%, specificity = 66.7%, positive predictive value = 29.4% and negative predictive value = 88.9%). Elevated TyG values (≥9.04) were positively associated with cardiometabolic risk factors (total cholesterol, LDL, VLDL, uric acid, alanine aminotransferase, aspartate aminotransferase, waist-hip ratio, systolic blood pressure, HOMA-IR, smoking, metabolic syndrome, diabetes, and hepatic steatosis). After adjustment for confounding factors, individuals with high TyG showed an increase of 69% (RP = 1.69; 95%CI = 1.03-2.78) in the prevalence of intermediate/high risk by FRS, compared to those with low TyG. Conclusion: The TyG index showed a good predictive capacity for cardiovascular risk in ten years assessed by the FRS.
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