Evidence map›Paper›PMID 36160910›Full record

ArticleExperimental and therapeutic medicine2022

Knockdown of triggering receptor expressed on myeloid cells 1 (TREM1) inhibits endoplasmic reticulum stress and reduces extracellular matrix degradation and the apoptosis of human nucleus pulposus cells.

Ji Zhang, Haoran Jiang, Min Li, Lixiang Ding

Abstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ji ZhangDepartment of Spine Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100089, P.R. China.
Haoran JiangDepartment of Spine Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100089, P.R. China.
Min LiDepartment of Clinical Medicine, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China.
Lixiang DingDepartment of Spine Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100089, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to the linear model of microarray data analysis, triggering receptor expressed on myeloid cells 1 (TREM1) has been shown to have a significantly different expression profile between intervertebral disc degeneration (IDD) samples and associated control samples. The purpose of the present study was to explore the probable role and underlying mechanism of TREM1 in IDD. To accomplish this, an

Indexed as

endoplasmic reticulum stresshuman nucleus pulposus cellsintervertebral disc degenerationToll-like receptor 4triggering receptor expressed on myeloid cells 1

Identifiers

PMID36160910
PMCPMC9468837

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.