ArticleFrontiers in physiology2022
Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Microgravity-induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies.Experimental physiology · 2026Review
- Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest.Nature communications · 2026Article
- Development of and adherence to artificial gravity and resistive vibration exercises during 60 days of hypoxic 6° head-down tilt bed rest: BRAVE study.Experimental physiology · 2026Article
- Review
- Muscle Weakness and the Irisin-BDNF and Oxidative Stress Axis in the 60-Day Pseudorandomised Controlled AGBRESA Bed Rest Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- The effect of artificial gravity on the outcome of a two-week resistance vibration exercise programme: BRAVE study.Experimental physiology · 2026Article
- Brain displacement and nonlinear deformation following human spaceflight.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research.British journal of clinical pharmacology · 2026Review
- Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit.NPJ microgravity · 2025Review
- Spaceflight Standard Measures is a multidisciplinary study that systematically monitors risks to astronaut health and performance.NPJ microgravity · 2025Review
- Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability.Frontiers in physiology · 2025Article
- Impact of Daily Lower-Body Negative Pressure or Cycling Followed by Venous Constrictive Thigh Cuffs on Bedrest-Induced Orthostatic Intolerance.Journal of the American Heart Association · 2024Article
- Artificial gravity: an effective countermeasure for microgravity-induced headward fluid shift?Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Effect of artificial gravity on neurocognitive performance during head-down tilt bedrest.NPJ microgravity · 2024Article
- Acute cardiovascular and muscular response to rowing ergometer exercise in artificial gravity - a pilot trial.NPJ microgravity · 2024Article
- Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.NPJ microgravity · 2024Article
- The impact of bed rest on human skeletal muscle metabolism.Cell reports. Medicine · 2024Article
- Personality matters in extremely demanding environments: A bed rest performance study.Frontiers in psychology · 2024Article
- Human gut microbiome and metabolite dynamics under simulated microgravity.Gut microbes · 2023Article
- Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
Corrections and comments
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A comprehensive strategy is required to mitigate risks to astronauts' health, well-being, and performance. This strategy includes developing countermeasures to prevent or reduce adverse responses to the stressors astronauts encounter during spaceflight, such as weightlessness. Because artificial gravity (AG) by centrifugation simultaneously affects all physiological systems, AG could mitigate the effects of weightlessness in multiple systems. In 2019, NASA and the German Aerospace Center conducted a 60-days Artificial Gravity Bed Rest Study with the European Space Agency (AGBRESA). The objectives of this study were to 1) determine if 30 min of AG daily is protective during head down bed rest, and 2) compare the protective effects of a single daily bout (30 min) of AG versus multiple daily bouts (6 × 5 min) of AG (1 Gz at the center of mass) on physiological functions that are affected by weightlessness and by head-down tilt bed rest. The AGBRESA study involved a comprehensive suite of standard and innovative technologies to characterize changes in a broad spectrum of physiological systems. The current article is intended to provide a detailed overview of the methods used during AGBRESA.
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