Evidence map›Paper›PMID 36160837›Full record

ArticleInternational journal of nephrology2022

COVID-19 Rapid Antigen Test Screening in Patients on Hemodialysis.

Gaetano Alfano, Roberta Scarmignan, Niccolò Morisi, Francesco Fontana, Silvia Giovanella, Giulia Ligabue, Laura Rofrano, William Gennari, Monica Pecorari, Mariacristina Gregorini and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. The Implementation and Role of Antigen Rapid Test for COVID-19 in Hemodialysis Units.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Gaetano AlfanoNephrology, Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.ORCID https://orcid.org/0000-0003-0591-8622
Roberta ScarmignanSurgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Via Del Pozzo 71, Modena 41124, Italy.
Niccolò MorisiSurgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Via Del Pozzo 71, Modena 41124, Italy.
Francesco FontanaNephrology, Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.ORCID https://orcid.org/0000-0003-0762-0942
Silvia GiovanellaSurgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Via Del Pozzo 71, Modena 41124, Italy.
Giulia LigabueSurgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Via Del Pozzo 71, Modena 41124, Italy.
Laura RofranoClinical Microbiology Unit, University Hospital of Modena, Modena, Italy.
William GennariMolecular Microbiology and Virology Unit, Department of Laboratory Medicine and Pathological Anatomy, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
Monica PecorariMolecular Microbiology and Virology Unit, Department of Laboratory Medicine and Pathological Anatomy, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
Mariacristina GregoriniNephrology and Dialysis, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy.
Gianni CappelliNephrology, Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.
Riccardo MagistroniNephrology, Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.
Gabriele DonatiNephrology, Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.ORCID https://orcid.org/0000-0001-8549-1221
University of Modena and Reggio Emilia · ITAzienda Ospedaliero-Universitaria di Modena · ITAzienda Sanitaria Unità Locale di Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Patients receiving in-center hemodialysis are extremely vulnerable to COVID-19. It is unclear if routine screening of asymptomatic hemodialysis patients is an effective strategy to prevent COVID-19 outbreaks within the dialysis unit. Methods: We conducted a retrospective analysis of in-center hemodialysis patients who underwent bimonthly COVID-19 rapid antigen test screening from February 15 Results: Overall, 4079 rapid antigen tests were performed in 277 hemodialysis patients on chronic hemodialysis with a mean age of 68.4 ± 14.6 years. Thirty-eight (0.9%) rapid antigen tests resulted positive. Only five (13.8%) positive-rapid antigen tests were also positive by RT-PCR testing. During the same period, 219 patients regularly screened by rapid antigen tests bimonthly underwent 442 RT-PCR nasopharyngeal swabs for clinical reasons. RT-PCR testing yielded a positive result in 13 (5.9%) patients. The time elapsed between PCR and the negative-rapid antigen test was 7.7 ± 4.6 days (range 1.8-13.9 days). At the end of the follow-up, 6.4% of the population on in-center hemodialysis contracted COVID-19, and routine rapid antigen tests detected only 5 out of 18 (27.7%) COVID-19 cases. No outbreaks of COVID-19 were identified within the dialysis unit. Conclusion: Bimonthly rapid antigen screening led to the early diagnosis of COVID-19 in less than one-third of cases. The short incubation period of the new SARS-CoV-2 variants makes bimonthly test screening inadequate for an early diagnosis of COVID-19. More frequent tests are probably necessary to improve the utility of COVID-19 nasal rapid antigen test in patients on hemodialysis.

Identifiers

PMID36160837
PMCPMC9492408
OpenAlexW4295786233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.