Evidence map›Paper›PMID 36160652›Full record

ArticleWorld journal of gastroenterology2022

Trends in hospitalization for alcoholic hepatitis from 2011 to 2017: A USA nationwide study.

Ali Wakil, Mujtaba Mohamed, Zaid Tafesh, Mumtaz Niazi, Raquel Olivo, Weiyi Xia, Patricia Greenberg, Nikolaos Pyrsopoulos

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Article in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ali WakilDepartment of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Mujtaba MohamedDepartment of Gastroenterology and Hepatology, Marshall University Hospital, Huntington, WV 25701, USA.
Zaid TafeshDepartment of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Mumtaz NiaziDepartment of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Raquel OlivoDepartment of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Weiyi XiaDepartment of Biostatistics & Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Patricia GreenbergDepartment of Biostatistics & Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Nikolaos PyrsopoulosDepartment of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA. pyrsopni@njms.rutgers.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere alcoholic hepatitis (AH) is one of the most lethal manifestations of alcohol-associated liver disease. In light of the increase in alcohol consumption worldwide, the incidence of AH is on the rise, and data examining the trends of AH admission is needed.

aimTo examine inpatient admission trends secondary to AH, along with their clinical outcomes and epidemiological characteristics.

methodsThe National Inpatient Sample (NIS) database was utilized, and data from 2011 to 2017 were reviewed. We included individuals aged ≥ 21 years who were admitted with a primary or secondary diagnosis of AH using the International Classification of Diseases (ICD)-9 and its correspondent ICD-10 codes. Hepatitis not related to alcohol was excluded. The national estimates of inpatient admissions were obtained using sample weights provided by the NIS.

resultsAH-related hospitalization demonstrated a significant increase in the USA from 281506 (0.7% of the total admission in 2011) to 324050 (0.9% of the total admission in 2017). The median age was 54 years. The most common age group was 45-65 years (range 57.8%-60.7%). The most common race was white (63.2%-66.4%), and patients were predominantly male (69.7%-71.2%). The primary healthcare payers were Medicare (29.4%-30.7%) and Medicaid (21.5%-32.5%). The most common geographical location was the Southern USA (33.6%-34.4%). Most patients were admitted to a tertiary care center (50.2%-62.3%) located in urban areas. Mortality of AH in this inpatient sample was 5.3% in 2011 and 5.5% in 2017. The most common mortality-associated risk factors were acute renal failure (59.6%-72.1%) and gastrointestinal hemorrhage (17.2%-20.3%). The total charges were noted to range between $25242.62 and $34874.50.

conclusionThe number of AH inpatient hospitalizations significantly increased from 2011 to 2017. This could have a substantial financial impact with increasing healthcare costs and utilization. AH-mortality remained the same.

Indexed as

Hepatitis, AlcoholicAgedFemaleHospitalizationHospital MortalityHumansLength of StayMaleMedicareMiddle AgedUnited StatesAlcohol abuseAlcoholic hepatitisCirrhosisFatty liver disease

Identifiers

PMID36160652
PMCPMC9494933

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.