ArticleArchives of medical science : AMS2022
A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI).
Article in Archives of medical science : AMS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights.Brain and behavior · 2026Review
- Effect of paeoniflorin on neuronal autophagy and Notch expression in tethered spinal cord in rats.Archives of medical science : AMS · 2025Article
- Cellular therapy for traumatic brain injury in adults: a meta-analysis of controlled clinical trials.Archives of medical science : AMS · 2025Review
- Spinal Cord Injury: From MicroRNAs to Exosomal MicroRNAs.Molecular neurobiology · 2024Review
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Authors and funding
3 authors.
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Abstract
Introduction: In this study, we aimed to investigate the role of rs531564 and the underlying signaling pathways. Methods: Five hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression. Results: By luciferase assays, we validated Bcl-2-like protein 11 (BIM) as a target gene of miR-124 with a negative regulatory relationship between them. We also observed that miR-124 suppressed cell viability and accelerated cell apoptosis. Conclusions: rs531564 could affect the expression of BIM by reducing the expression of miR-124, and it could be a bio-marker for the length of recovery after SCI.
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