ReviewFrontiers in microbiology2022
Progress in structural and functional study of the bacterial phenylacetic acid catabolic pathway, its role in pathogenicity and antibiotic resistance.
Review in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- From planktonic to biofilm states: single-cell transcriptomics reveals metabolic reprogramming and cellular heterogeneity inBiofilm · 2026Article
- Biofilm-driven LPS remodeling and colanic acid overproduction mediate biocide adaptation and antibiotic cross-resistance in E. coli.npj antimicrobials and resistance · 2026Article
- Conservation, origin, and remodeling of the phenyl acetate degradation pathway.Microbial genomics · 2026Article
- ComparativeFoods (Basel, Switzerland) · 2026Article
- Genomic perplexity and the evolution of context-dependent function.Molecular biology and evolution · 2026Article
- Genome-wide screening of antibiotic survival genes in Escherichia coli MG1655.BMC microbiology · 2026Article
- Article
- The interactive relationship between Fusobacterium necrophorum, Bacteroides pyogenes, and Porphyromonas levii in driving inflammatory uterine disease.Microbiome · 2026Article
- Clinical impact of altered gut microbiota and metabolite profiles on mortality in patients with candidemia: a prospective observational pilot cohort study.Annals of clinical microbiology and antimicrobials · 2026Observational
- Analysis of Toxic Components in Secondary Metabolites of Entomopathogenic FungiMicroorganisms · 2025Article
- Insights into the Metabolic Adaptations of a Carbapenem-ResistantInternational journal of molecular sciences · 2025Article
- Crystal structures of 3,4,5-tri-phenyl-toluene and 3,4,5-tri-phenyl-benzyl bromide.Acta crystallographica. Section E, Crystallographic communications · 2025Article
- Bioprospecting Antarctic Microorganisms: InvestigatingJournal of microbiology and biotechnology · 2025Article
- Multi-omics assessment of gut microbiota in circadian rhythm disorders: a cross-sectional clinical study.Frontiers in cellular and infection microbiology · 2025Article
- A comprehensive investigation of the anion inhibition profile of a β-carbonic anhydrase fromJournal of enzyme inhibition and medicinal chemistry · 2024Article
- Crystal structure of an aceto-nitrile solvate of 2-(3,4,5-triphen-ylphen-yl)acetic acid.Acta crystallographica. Section E, Crystallographic communications · 2024Article
- Production of Toxins by the Gut Microbiota: The Role of Dietary Protein.Current nutrition reports · 2024Review
- Genome analysis and hyphal movement characterization of the hitchhiker endohyphalApplied and environmental microbiology · 2024Article
- Sphingomicrobium clamense sp. nov., Isolated from Sediment of Clam Island Beach in China.Current microbiology · 2024Article
- Probiotic-Fermented Distillers Grain Alters the Rumen Microbiome, Metabolome, and Enzyme Activity, Enhancing the Immune Status of Finishing Cattle.Animals : an open access journal from MDPI · 2023Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenylacetic acid (PAA) is a central intermediate metabolite involved in bacterial degradation of aromatic components. The bacterial PAA pathway mainly contains 12 enzymes and a transcriptional regulator, which are involved in biofilm formation and antimicrobial activity. They are present in approximately 16% of the sequenced bacterial genome. In this review, we have summarized the PAA distribution in microbes, recent structural and functional study progress of the enzyme families of the bacterial PAA pathway, and their role in bacterial pathogenicity and antibiotic resistance. The enzymes of the bacterial PAA pathway have shown potential as an antimicrobial drug target for biotechnological applications in metabolic engineering.
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