Evidence map›Paper›PMID 36160040›Full record

ArticleCell reports methods2022

Facile detection of mechanical forces across proteins in cells with STReTCh.

Brian L Zhong, Vipul T Vachharajani, Alexander R Dunn

Open access · goldAbstract read
In one paragraph

Article in Cell reports methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brian L ZhongDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Vipul T VachharajaniGraduate Program in Biophysics, Stanford University, Stanford, CA 94305, USA.
Alexander R DunnDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Stanford University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
Molecular mechanisms underlying force transduction at cellular adhesion complexesR35GM130332 · NIGMS · STANFORD UNIVERSITY · PI Alexander R Dunn · 2019 to 2026
$4.9M
Stanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020
$1.2M
Molecular Basis of Renal Epithelial Cell-Cell AdhesionF30DK124985 · NIDDK · STANFORD UNIVERSITY · PI VACHHARAJANI, VIPUL · 2020 to 2022
$109k
Howard Hughes Medical InstituteNIDDK NIH HHS F30 DK124985NIGMS NIH HHS R35 GM130332NIGMS NIH HHS T32 GM007365NIGMS NIH HHS T32 GM120007
6 · The paper itself

Abstract

Numerous proteins experience and respond to mechanical forces as an integral part of their cellular functions, but measuring these forces remains a practical challenge. Here, we present a compact, 11-kDa molecular tension sensor termed STReTCh (sensing tension by reactive

Indexed as

CytoskeletonMechanical PhenomenaCytoskeletal ProteinsMicrotubulesCytoskeletal Proteinsbiosensorcell adhesioncytoskeletonmechanical forcemechanobiology

Identifiers

PMID36160040
PMCPMC9499875
OpenAlexW4294151558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.