Evidence map›Paper›PMID 36159850›Full record

ArticleFrontiers in immunology2022

Maturation of circulating Ly6C

Anastasia Dagkonaki, Athina Papalambrou, Maria Avloniti, Areti Gkika, Maria Evangelidou, Maria-Eleni Androutsou, Theodore Tselios, Lesley Probert

Abstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anastasia DagkonakiLaboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.
Athina PapalambrouLaboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.
Maria AvlonitiLaboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.
Areti GkikaDepartment of Chemistry, University of Patras, Patras, Greece.
Maria EvangelidouLaboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.
Maria-Eleni AndroutsouResearch and Development Department, Vianex PLC, Nea Erythrea, Greece.
Theodore TseliosDepartment of Chemistry, University of Patras, Patras, Greece.
Lesley ProbertLaboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune diseases affecting the CNS not only overcome immune privilege mechanisms that protect neural tissues but also peripheral immune tolerance mechanisms towards self. Together with antigen-specific T cells, myeloid cells are main effector cells in CNS autoimmune diseases such as multiple sclerosis, but the relative contributions of blood-derived monocytes and the tissue resident macrophages to pathology and repair is incompletely understood. Through the study of oxidized mannan-conjugated myelin oligodendrocyte glycoprotein 35-55 (OM-MOG), we show that peripheral maturation of Ly6C

Indexed as

EncephalomyelitisEncephalomyelitis, Autoimmune, ExperimentalAnimalsAntigens, LyImmune ToleranceMannansMiceMice, KnockoutMonocytesMyelin-Oligodendrocyte GlycoproteinPeptidesReceptors, CCR2Antigens, LyCcr2 protein, mouseLy-6C antigen, mouseMannansMog protein, mouseMyelin-Oligodendrocyte GlycoproteinPeptidesReceptors, CCR2demyelinationEAEimmunotherapyMDSCmonocyte maturationmultiple sclerosisPD-L1, Cre/loxP mouse

Identifiers

PMID36159850
PMCPMC9501702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.