Evidence map›Paper›PMID 36159826›Full record

ArticleFrontiers in immunology2022

Cytokine competent gut-joint migratory T Cells contribute to inflammation in the joint.

Adam R Lefferts, Eric Norman, David J Claypool, Uma Kantheti, Kristine A Kuhn

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

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  8. Gut and Joint Microbiomes: Implications in Osteoarthritis.Rheumatic diseases clinics of North America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Adam R LeffertsDivision of Rheumatology, University of Colorado, Aurora, CO, United States.
Eric NormanDivision of Rheumatology, University of Colorado, Aurora, CO, United States.
David J ClaypoolDivision of Rheumatology, University of Colorado, Aurora, CO, United States.
Uma KanthetiDivision of Rheumatology, University of Colorado, Aurora, CO, United States.
Kristine A KuhnDivision of Rheumatology, University of Colorado, Aurora, CO, United States.
University of Colorado Denver · USUniversity of Colorado Anschutz Medical Campus · US

Funding

University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANE E REUSCH · 2020 to 2026
$10.8M
Research Training in Rheumatology INCLUDE Down Syndrome SupplementT32AR007534 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Kristine A. Kuhn · 1986 to 2026
$6.1M
Core 2 - Mucosal Immunobiology Core (MIC)P30AR079369 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Vernon Michael Holers · 2021 to 2026
$4.7M
The role of bacteria-produced indole in the development of autoimmune arthritisR01AR075033 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Kristine A. Kuhn · 2019 to 2026
$3.1M
Development of colonic intraepithelial lymphocytes and their role in epithelial and immune functionK08DK107905 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI KUHN, KRISTINE A. · 2016 to 2020
$716k
NIAMS NIH HHS P30 AR079369NIAMS NIH HHS R01 AR075033NIAMS NIH HHS T32 AR007534NIDDK NIH HHS K08 DK107905NIDDK NIH HHS P30 DK116073
6 · The paper itself

Abstract

Although studies have identified the presence of gut-associated cells in the enthesis of joints affected by spondylarthritis (SpA), a direct link through cellular transit between the gut and joint has yet to be formally demonstrated. Using KikGR transgenic mice to label

Indexed as

Interleukin-17SpondylarthritisAnimalsAnti-Bacterial AgentsCytokinesHomeodomain ProteinsInflammationMiceMice, TransgenicAnti-Bacterial AgentsCytokinesHomeodomain ProteinsInterleukin-17cellular traffickingIL-17inflammationinflammatory bowel diseasespondyloarthritis (SpA)T cellsTNF

Identifiers

PMID36159826
PMCPMC9489919
OpenAlexW4297264322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.