Evidence map›Paper›PMID 36159818›Full record

ArticleFrontiers in immunology2022

Development and validation of a necroptosis-related gene prognostic score to predict prognosis and efficiency of immunotherapy in gastric cancer.

Yan Xia, Rongzheng Zhang, Mingzhu Wang, Jiaqi Li, Jianming Dong, Kaitong He, Ting Guo, Xiaomei Ju, Jiaqiu Ru, Shuyun Zhang and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Interaction of HIF-1a with various cell death pathways in tumor immune microenvironment (TIME).Apoptosis : an international journal on programmed cell death · 2026
    Pooled it
  2. Review
  3. Research progress on the expression characteristics, biological functions, and therapeutic potential of NOX4 in malignant tumors: a functional perspective.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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  9. Predictive significance of MPT-driven necrosis-related genes signature in gastric cancer and their impact on the tumor microenvironment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  10. Pan-cancer analysis reveals the prognostic and immunomodulatory potential of super-enhancer-induced ANGPT2 and experimental validation in colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan XiaDepartment of Clinical Laboratory, Harbin Medical University Cancer Hospital, Harbin, China.
Rongzheng ZhangScientific Research Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Mingzhu WangDepartment of Clinical Laboratory, Harbin Medical University Cancer Hospital, Harbin, China.
Jiaqi LiScientific Research Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jianming DongScientific Research Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Kaitong HeDepartment of Clinical Laboratory, Harbin Medical University Cancer Hospital, Harbin, China.
Ting GuoDepartment of Clinical Laboratory, Harbin Medical University Cancer Hospital, Harbin, China.
Xiaomei JuScientific Research Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jiaqiu RuScientific Research Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Shuyun ZhangScientific Research Center, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yihua SunDepartment of Clinical Laboratory, Harbin Medical University Cancer Hospital, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necroptosis is a novel type of regulated cell death that is intimately associated with a variety of tumors. However, how necroptosis affects the identification of gastric cancer (GC) remains unclear. Here we seek to find new potential necroptosis-related biomarkers to predict GC prognosis and immunotherapy effect. We used Cox analysis to obtain shared prognostic markers related to necroptosis from five datasets (TCGA and four GEO datasets). Then, a necroptosis-related gene prognostic score (NRGPS) system was constructed using LASSO Cox regression, NRGPS consisting of three necroptosis-related mRNAs (

Indexed as

Stomach NeoplasmsBiomarkers, TumorHumansImmunologic FactorsImmunotherapyMicrosatellite InstabilityNecroptosisPrognosisTumor MicroenvironmentBiomarkers, TumorImmunologic Factorsbioinformatics analysisgastric cancernecroptosis geneprognosistumor microenvironment

Identifiers

PMID36159818
PMCPMC9504871

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.