Evidence map›Paper›PMID 36159712›Full record

ReviewNeurophotonics2022

Building bridges: simultaneous multimodal neuroimaging approaches for exploring the organization of brain networks.

Evelyn M R Lake, Michael J Higley

Abstract readReview
In one paragraph

Review in Neurophotonics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Biphasic acclimation for simultaneous wide-field fluorescent CaImaging neuroscience (Cambridge, Mass.) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Evelyn M R LakeYale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, Connecticut, United States.ORCID https://orcid.org/0000-0001-8255-8013
Michael J HigleyYale School of Medicine, Departments of Neuroscience and Psychiatry, New Haven, Connecticut, United States.

Funding

Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI In-Jung Kim · 2016 to 2026
$7.1M
Cellular mechanisms of GABAergic inhibition in neocortical dendritesR01MH099045 · NIMH · YALE UNIVERSITY · PI Michael James Higley · 2012 to 2026
$5.7M
Role of GABAergic interneurons in developmental dysregulation of cortical functionR01MH113852 · NIMH · YALE UNIVERSITY · PI CARDIN, JESSICA A, HIGLEY, MICHAEL JAMES · 2017 to 2021
$2.1M
Cellular mechanisms of GABAergic inhibition in neocortical dendritesR56MH099045 · NIMH · YALE UNIVERSITY · PI HIGLEY, MICHAEL JAMES · 2024 to 2024
$606k
Leveraging simultaneous BOLD-fMRI and wide-field Ca2+ imaging to reveal measures of neurovascular health that cross scales and species which have AD symptom and treatment response prognostic utilityR21AG075778 · NIA · YALE UNIVERSITY · PI LAKE, EVELYN MR · 2022 to 2022
$461k
Behavior-dependent classification of neocortical cell typesR21MH121841 · NIMH · YALE UNIVERSITY · PI HIGLEY, MICHAEL JAMES · 2020 to 2021
$461k
NEI NIH HHS P30 EY026878NIA NIH HHS R21 AG075778NIMH NIH HHS R01 MH099045NIMH NIH HHS R01 MH113852NIMH NIH HHS R21 MH121841NIMH NIH HHS R56 MH099045
6 · The paper itself

Abstract

Brain organization is evident across spatiotemporal scales as well as from structural and functional data. Yet, translating from micro- to macroscale (vice versa) as well as between different measures is difficult. Reconciling disparate observations from different modes is challenging because each specializes within a restricted spatiotemporal milieu, usually has bounded organ coverage, and has access to different contrasts. True intersubject biological heterogeneity, variation in experiment implementation (e.g., use of anesthesia), and true moment-to-moment variations in brain activity (maybe attributable to different brain states) also contribute to variability between studies. Ultimately, for a deeper and more actionable understanding of brain organization, an ability to translate across scales, measures, and species is needed. Simultaneous multimodal methods can contribute to bettering this understanding. We consider four modes, three optically based: multiphoton imaging, single-photon (wide-field) imaging, and fiber photometry, as well as magnetic resonance imaging. We discuss each mode as well as their pairwise combinations with regard to the definition and study of brain networks.

Indexed as

brain networksfiber photometrymagnetic resonance imagingmultiphoton imagingsimultaneous imagingsingle-photon imaging

Identifiers

PMID36159712
PMCPMC9506627

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.