Evidence map›Paper›PMID 36159668›Full record

ReviewFrontiers in bioengineering and biotechnology2022

Recent advances in nano-drug delivery systems for synergistic antitumor immunotherapy.

Bonan Zhao, Xiang Li, Ying Kong, Wenbo Wang, Tingting Wen, Yanru Zhang, Zhiyong Deng, Yafang Chen, Xian Zheng

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  3. Iron-Based Nanoparticles as Delivery Tools.Pharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bonan ZhaoLeiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, Netherlands.
Xiang LiDepartment of Central Laboratory and Precision Medicine Center, Department of Nephrology, The Affiliated Huai'an Hospital of Xuzhou Medical University and Huai'an Second People's Hospital, Huai'an, China.
Ying KongDepartment of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Wenbo WangDepartment of Pharmacy, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.
Tingting WenDepartment of Pharmacy, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.
Yanru ZhangDepartment of Pharmacy, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.
Zhiyong DengDepartment of Pathology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.
Yafang ChenDepartment of Pharmacy, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.
Xian ZhengDepartment of Pharmacy, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy has demonstrated great clinical success in the field of oncology in comparison with conventional cancer therapy. However, cancer immunotherapy still encounters major challenges that limit its efficacy against different types of cancers and the patients show minimal immune response to the immunotherapy. To overcome these limitations, combinatorial approaches with other therapeutics have been applied in the clinic. Simultaneously, nano-drug delivery system has played an important role in increasing the antitumor efficacy of various treatments and has been increasingly utilized for synergistic immunotherapy to further enhance the immunogenicity of the tumors. Specifically, they can promote the infiltration of immune cells within the tumors and create an environment that is more sensitive to immunotherapy, particularly in solid tumors, by accelerating tumor accumulation and permeability. Herein, this progress report provides a brief overview of the development of nano-drug delivery systems, classification of combinatory cancer immunotherapy and recent progress in tumor immune synergistic therapy in the application of nano-drug delivery systems.

Indexed as

cancer therapyimmunotherapynano-drug delivery systemsnanomedicinesynergistic treatment

Identifiers

PMID36159668
PMCPMC9497653

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.